| Pyrene excimer nucleic acid probes for biomolecule signaling. | |
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MedLine Citation:
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PMID: 20201423 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pyrene excimer nucleic acid probes are novel molecular probes that integrate the unique optical properties of pyrene excimer with excellent recognition capability of nucleic acids. Pyrene has the property of forming excimer that has a large Stokes shift and long fluorescence lifetime. Nucleic acid probes, like aptamers and molecular beacons, can directly bind to target molecules with a high selectivity and affinity. Possessing these outstanding characteristics of pyrene excimer and nucleic acid probes, pyrene excimer nucleic acid probes can be effectively used in detection of biomolecules, study of protein-DNA interactions, and investigation of enzymatic processes in complex biological systems. In this review, we will discuss the optical properties of pyrene excimer and summarize recent progresses on pyrene excimer signaling nucleic acid probes for the signaling of biomolecules and their interactions in complex biological samples. |
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Authors:
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Cuichen Wu; Chunming Wang; Ling Yan; Chaoyong James Yang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Journal of biomedical nanotechnology Volume: 5 ISSN: 1550-7033 ISO Abbreviation: J Biomed Nanotechnol Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2010-03-05 Completed Date: 2010-04-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101230869 Medline TA: J Biomed Nanotechnol Country: United States |
Other Details:
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Languages: eng Pagination: 495-504 Citation Subset: IM |
Affiliation:
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Department of Chemical Biology, College of Chemistry and Chemical Engineering, Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen 361005, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biopolymers / analysis*, metabolism* Biosensing Techniques / methods* Humans Microscopy, Fluorescence / methods Molecular Probe Techniques* Nucleic Acids / chemistry* Pyrenes / chemistry* Signal Transduction / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Biopolymers; 0/Nucleic Acids; 0/Pyrenes; 129-00-0/pyrene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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