Document Detail

Pyomelanin is produced by Shewanella algae BrY and affected by exogenous iron.
MedLine Citation:
PMID:  18389008     Owner:  NLM     Status:  MEDLINE    
Melanin production by Shewanella algae BrY occurred during late- and (or) post-exponential growth in lactate basal salts liquid medium supplemented with tyrosine or phenylalanine. The antioxidant ascorbate inhibited melanin production but not production of the melanin precursor homogentisic acid. In the absence of ascorbate, melanin production was inhibited by the 4-hydroxyphenylpyruvate dioxygenase inhibitor sulcotrione and by concentrations of Fe >or= 0.38 mmol L(-1). These data support the hypothesis that pigment production by S. algae BrY was a result of the conversion of tyrosine or phenylalanine to homogentisic acid, which was excreted, auto-oxidized, and self-polymerized to form pyomelanin. Pyomelanin production by S. algae BrY may play an important role in the biogeochemical cycling of Fe in the environment.
Charles E Turick; Frank Caccavo; Louis S Tisa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Canadian journal of microbiology     Volume:  54     ISSN:  0008-4166     ISO Abbreviation:  Can. J. Microbiol.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-04     Completed Date:  2008-07-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372707     Medline TA:  Can J Microbiol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  334-9     Citation Subset:  IM    
Environmental Biotechnology Section, Savannah River National Laboratory, Building 999W, Aiken, SC 29808, USA.
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MeSH Terms
4-Hydroxyphenylpyruvate Dioxygenase / antagonists & inhibitors,  metabolism
Cyclohexanones / metabolism
Homogentisic Acid / metabolism
Iron / metabolism,  pharmacology*
Melanins / biosynthesis*,  metabolism
Mesylates / metabolism
Shewanella / drug effects,  enzymology,  growth & development,  metabolism*
Reg. No./Substance:
0/Cyclohexanones; 0/Melanins; 0/Mesylates; 0/melanin precursors; 0/pyomelanin; 451-13-8/Homogentisic Acid; 7439-89-6/Iron; 99105-77-8/sulcotrione; EC Dioxygenase

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