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Pyogenic granulomas during isotretinoin therapy.
MedLine Citation:
PMID:  21886758     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: A review of scientific literature reveals a sparse documentation of periungual pyogenic granulomas as an adverse effect of isotretinoin therapy
MAIN OBSERVATIONS: Periungual pyogenic granulomas appeared in four patients receiving isotretinoin therapy for severe acne. Oral and topical antibiotic treatments were ineffective and all cases spontaneously resolved once isotretinoin is discontinued.
CONCLUSION: This report demonstrates the idiosyncratic nature of this side effect. We suggest that, although infection is possible due to the transformed nature of the normally protective skin barrier, oral and topical antibiotic treatments appear ineffective. Pyogenic granulomas spontaneously resolve once isotretinoin is discontinued.
Authors:
Kathleen Armstrong; Miriam Weinstein
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of dermatological case reports     Volume:  5     ISSN:  1898-7249     ISO Abbreviation:  J Dermatol Case Rep     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-09-02     Completed Date:  2011-11-10     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101493700     Medline TA:  J Dermatol Case Rep     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  5-7     Citation Subset:  -    
Affiliation:
Paediatric Dermatology Hospital For Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada, M5G 1X8.
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