| Pyodermatitis-pyostomatitis vegetans: a clinical course of two decades with response to cyclosporine and low-dose prednisolone. | |
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MedLine Citation:
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PMID: 11501652 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pyodermatitis-pyostomatitis vegetans is a rare, polymorphous inflammatory disorder of the skin and oral mucosa first described by Hallopeau in 1898. On the skin papules, pustules and reddish brown annular vegetating plaques develop, most frequently in the intertriginous areas. In the mouth, yellowish flat ulcerations arise, typically in the shape of "snail tracks". The association with inflammatory bowel disease is very common. An unusual case with a chronic relapsing course of 2 decades is presented. Gastrointestinal inflammation was absent. Prednisolone in high and medium doses suppressed most lesions. Various attempts with other drugs (dapsone, isotretinoin, azathioprine) to reduce the corticosteroid dose failed. This is the first report of the successful treatment of pyodermatitis-pyostomatitis vegetans with cyclosporin A, which proved to be highly effective in this regard. The unknown aetiopathology of pyodermatitis-pyostomatitis vegetans is discussed. |
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Authors:
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T Brinkmeier; P J Frosch |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Acta dermato-venereologica Volume: 81 ISSN: 0001-5555 ISO Abbreviation: Acta Derm. Venereol. Publication Date: 2001 May |
Date Detail:
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Created Date: 2001-08-14 Completed Date: 2001-12-07 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370310 Medline TA: Acta Derm Venereol Country: Norway |
Other Details:
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Languages: eng Pagination: 134-6 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Staedtische Kliniken Dortmund, Germany. stkd.hautklinik@dokom.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-Inflammatory Agents / therapeutic use* Cyclosporine / therapeutic use* Drug Therapy, Combination Humans Immunosuppressive Agents / therapeutic use* Male Methylprednisolone / therapeutic use* Mouth Mucosa / pathology Pyoderma / drug therapy*, pathology Stomatitis / drug therapy*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Immunosuppressive Agents; 59865-13-3/Cyclosporine; 83-43-2/Methylprednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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