Document Detail

Pyodermatitis-pyostomatitis vegetans: a clinical course of two decades with response to cyclosporine and low-dose prednisolone.
MedLine Citation:
PMID:  11501652     Owner:  NLM     Status:  MEDLINE    
Pyodermatitis-pyostomatitis vegetans is a rare, polymorphous inflammatory disorder of the skin and oral mucosa first described by Hallopeau in 1898. On the skin papules, pustules and reddish brown annular vegetating plaques develop, most frequently in the intertriginous areas. In the mouth, yellowish flat ulcerations arise, typically in the shape of "snail tracks". The association with inflammatory bowel disease is very common. An unusual case with a chronic relapsing course of 2 decades is presented. Gastrointestinal inflammation was absent. Prednisolone in high and medium doses suppressed most lesions. Various attempts with other drugs (dapsone, isotretinoin, azathioprine) to reduce the corticosteroid dose failed. This is the first report of the successful treatment of pyodermatitis-pyostomatitis vegetans with cyclosporin A, which proved to be highly effective in this regard. The unknown aetiopathology of pyodermatitis-pyostomatitis vegetans is discussed.
T Brinkmeier; P J Frosch
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  81     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-08-14     Completed Date:  2001-12-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  134-6     Citation Subset:  IM    
Department of Dermatology, Staedtische Kliniken Dortmund, Germany.
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MeSH Terms
Anti-Inflammatory Agents / therapeutic use*
Cyclosporine / therapeutic use*
Drug Therapy, Combination
Immunosuppressive Agents / therapeutic use*
Methylprednisolone / therapeutic use*
Mouth Mucosa / pathology
Pyoderma / drug therapy*,  pathology
Stomatitis / drug therapy*,  pathology
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Immunosuppressive Agents; 59865-13-3/Cyclosporine; 83-43-2/Methylprednisolone

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