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Pyoderma gangrenosum with oral involvement - case report and review of the literature.
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MedLine Citation:
PMID:  20737938     Owner:  NLM     Status:  MEDLINE    
Pyoderma gangrenosum (PG) is a rare, noninfectious neutrophilic dermatosis. Clinically, it begins with sterile pustules that rapidly progress into painful ulcers of variable depth and size with undermined violaceous borders. The diagnosis of PG is based on the history of an underlying disease, a typical clinical presentation, histopathology, and exclusion of other diseases. The peak incidence occurs between the ages of 20 to 50 years with women being more often affected than men. There have been very few reports of pyoderma gangrenosum with oral mucosal involvement. Oral lesions in previously reported cases have included ulcers of varying sizes from a few mm to several cm and have been reported to have been found on the tongue, soft and hard palate, buccal mucosa, and gingiva. Some of these oral lesions have been associated with ulcerative colitis, inflammatory bowel disease, and polycythemia rubra vera. A few cases were reported with biopsy findings, the histological picture being nonspecific, showing ulceration, and necrosis with inflammatory cell infiltrate. A peculiar case of pyoderma gangrenosum with an oral lesion is presented here, and the differential diagnosis is discussed.
Geetha Paramkusam; Venkateswarlu Meduri; Naresh Gangeshetty
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  International journal of oral science     Volume:  2     ISSN:  1674-2818     ISO Abbreviation:  Int J Oral Sci     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-08-26     Completed Date:  2010-09-07     Revised Date:  2012-10-15    
Medline Journal Info:
Nlm Unique ID:  101504351     Medline TA:  Int J Oral Sci     Country:  China    
Other Details:
Languages:  eng     Pagination:  111-6     Citation Subset:  D; IM    
Department of Oral Medicine and Radiology, Kaminein Institute of Dental Sciences, Nagonda, India.
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MeSH Terms
Anti-Infective Agents / therapeutic use
Chlorhexidine / therapeutic use
Dapsone / therapeutic use
Drug Therapy, Combination
Glucocorticoids / therapeutic use
Metronidazole / therapeutic use
Oral Ulcer / drug therapy,  etiology*,  pathology
Prednisolone / therapeutic use
Pyoderma Gangrenosum / complications*
Tooth Mobility / etiology*
Reg. No./Substance:
0/Anti-Infective Agents; 0/Glucocorticoids; 443-48-1/Metronidazole; 50-24-8/Prednisolone; 55-56-1/Chlorhexidine; 80-08-0/Dapsone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Int J Oral Sci
Journal ID (iso-abbrev): Int J Oral Sci
ISSN: 1674-2818
ISSN: 2049-3169
Publisher: Nature Publishing Group
Article Information
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Copyright © 2010 West China School of Stomatology
Received Day: 28 Month: 01 Year: 2010
Revision Received Day: 23 Month: 03 Year: 2010
Accepted Day: 23 Month: 03 Year: 2010
Print publication date: Month: 06 Year: 2010
pmc-release publication date: Day: 1 Month: 6 Year: 2010
Volume: 2 Issue: 2
First Page: 111 Last Page: 116
ID: 3470099
Publisher Item Identifier: ijos201016
DOI: 10.4248/IJOS10032
PubMed Id: 20737938

Pyoderma Gangrenosum with Oral Involvement – Case Report and Review of the Literature
Geetha Paramkusam1
Venkateswarlu Meduri1
Naresh Gangeshetty1*
1Department of Oral Medicine and Radiology, Kaminein Institute of Dental Sciences, Nagonda, India
*Department of Oral Medicine and Radiology, Kaminein Institute of Dental Sciences, Sreepuram, Narketpally, Nagonda, Andhra Pradesh, India E-mail:

Article Categories:
  • Case Report

Keywords: pyoderma gangrenosum, oral lesion of pyoderma gangrenosum, diagnosis.

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