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Pyoderma gangrenosum: Study of 21 patients and proposal of a 'clinicotherapeutic' classification.
MedLine Citation:
PMID:  20666672     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Abstract Background: Pyoderma gangrenosum (PG) is a rare, relapsing inflammatory disorder classified within the neutrophilic dermatoses. It can be idiopathic or associated with various conditions. The management of PG includes several immunosuppressants, but definite guidelines are still lacking. Objective: To propose a 'clinicotherapeutic' classification for PG; namely, a therapeutic algorithm for this disease on the basis of the clinical extent of lesions. Methods: Twenty-one patients with PG referred to our department during the last 3½ years were prospectively studied. They were subdivided into three subsets - localized, multilesional and disseminated - on the basis of the number of lesions and percentage of involved body surface area. Results: The end point was fulfilled in all the aforementioned settings of PG. Topical tacrolimus proved to be useful in localized PG. Multilesional PG was successfully treated with prednisone alone or in combination with cyclosporine. Disseminated PG responded well to prednisone plus cyclosporine, except for refractory cases in which infliximab was employed. Conclusions: This clinicotherapeutic classification seems to work well in PG, although its impact on the incidence of relapses is poorly evaluable due to the short follow-ups in our study; controlled trials are needed to confirm its value.
Authors:
Angelo Valerio Marzano; Valentina Trevisan; Riccardo Lazzari; Carlo Crosti
Publication Detail:
Type:  Journal Article     Date:  2010-07-28
Journal Detail:
Title:  The Journal of dermatological treatment     Volume:  22     ISSN:  1471-1753     ISO Abbreviation:  J Dermatolog Treat     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8918133     Medline TA:  J Dermatolog Treat     Country:  England    
Other Details:
Languages:  eng     Pagination:  254-60     Citation Subset:  IM    
Affiliation:
Dermatology Unit - Department of Anesthesia , Intensive Care and Dermatologic Sciences, Università degli Studi di Milano - Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milan , Italy.
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