| Pygeum africanum: effect on oxidative stress in early diabetes-induced bladder. | |
| | |
MedLine Citation:
|
PMID: 19609708 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
OBJECTIVE: To evaluate the effect of Pygeum africanum on oxidative stress and functional changes of the bladder after diabetes induction. MATERIALS AND METHODS: Thirty-two adult Wistar male rats were treated daily for 8 weeks and grouped as follows: Control group (n = 6), Streptozotocin-induced diabetic group (n = 10), diabetes plus P. africanum group (n = 10), and control plus P. africanum group (n = 6). After diabetes induction for 4 weeks, the diabetes plus P. africanum and control plus P. africanum groups were fed with P. africanum (100 mg/kg, orally) in peanut oil for another 4 weeks. The catalase, superoxide dismutase activity, and malondialdehyde levels were measured as a marker of lipid peroxidation. The levels of inducible nitric oxide synthase were also evaluated. Urodynamic studies were performed to evaluate the functional changes of diabetic bladders after P. africanum treatment. RESULTS: The catalase and superoxide dismutase activities significantly increased (P < 0.05) and maleic dialdehyde levels significantly decreased from diabetic plus P. africanum group compared with diabetic group (P < 0.05). Immunohistochemical studies showed a significantly decreased number of inducible nitric oxide synthase-positive cells in diabetic plus P. africanum group compared with diabetic group (P < 0.05). In diabetic plus P. africanum group, maximal bladder volume significantly decreased, while bladder pressure and maximal bladder pressure significantly increased compared with diabetic group (P < 0.05). CONCLUSIONS: Early treatment with P. africanum could effectively suppress the oxidative stress status in diabetic bladder and may slow down the process of diabetic cystopathy. |
| | |
Authors:
|
Dan Wang; Yongzhi Li; Guihua Hou; Ping Wang; Jianping Zhang; Vincent Laudon; Benkang Shi |
Related Documents
:
|
6374968 - A study of serum free c-peptide responses to oral glucose load in diabetic patients: wi... 3123298 - Evaluation of an intensified insulin treatment and teaching programme as routine manage... 19923038 - Efficacy of ppar-γ agonist pioglitazone in mild alzheimer disease. 16837818 - Acquired loss of erythrocyte complement receptor type 1 in patients with diabetic nephr... 16839998 - Metabolic responses to lipid infusions in patients with liver cirrhosis. 11118018 - Pharmacokinetics and pharmacodynamics of subcutaneous injection of long-acting human in... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-07-16 |
Journal Detail:
|
Title: International urology and nephrology Volume: 42 ISSN: 1573-2584 ISO Abbreviation: Int Urol Nephrol Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-06-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0262521 Medline TA: Int Urol Nephrol Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 401-8 Citation Subset: IM |
Affiliation:
|
Institute of Experimental Nuclear Medicine, Shandong University School of Medicine, 44# Wenhua Xi Road, 250012, Jinan, Shandong, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A right renal angiomyolipoma with IVC thrombus and pulmonary embolism.
Next Document: Cancers and the concept of cell senescence.