Document Detail

Pyelonephritis during pregnancy: a cause for an acquired deficiency of protein Z.
MedLine Citation:
PMID:  18828054     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Pyelonephritis has a more severe course during pregnancy than in the non-pregnant state. This has been attributed to the increased susceptibility of pregnant women to microbial products. An acquired protein Z deficiency has been reported when there is excessive thrombin activity. The aim of this study was to determine whether pyelonephritis during pregnancy is associated with changes in maternal plasma protein Z concentrations.
STUDY DESIGN: A cross-sectional study was conducted to compare plasma protein Z concentrations between normal pregnant women (N = 71) and pregnant women with pyelonephritis (N = 42). Protein Z concentrations were measured by enzyme-linked immunosorbent assay. Parametric and non-parametric statistics were used for analysis.
RESULTS: Patients with pyelonephritis had a significantly lower median plasma concentration of protein Z than did patients with normal pregnancies (median 2.14 microg/mL (0.4-3.4) vs. median 2.36 microg/mL (1.09-3.36); p = 0.03). There was no difference in the median plasma concentration of anti-protein Z antibodies between patients with pyelonephritis and those with normal pregnancies.
CONCLUSION: The median maternal plasma protein Z concentration was significantly lower in patients with pyelonephritis during pregnancy than in patients with normal pregnancies.
Jyh Kae Nien; Roberto Romero; Debra Hoppensteadt; Offer Erez; Jimmy Espinoza; Eleazar Soto; Juan Pedro Kusanovic; Francesca Gotsch; Chong Jai Kim; Pooja Mittal; Jawed Fareed; Joaquin Santolaya; Tinnakorn Chaiworapongsa; Samuel Edwin; Beth Pineles; Sonia Hassan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  21     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-10-01     Completed Date:  2009-01-22     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  629-37     Citation Subset:  IM    
Perinatology Research Branch, NICHD, NIH, DHHS, Bethesda, Maryland, USA.
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MeSH Terms
Blood Proteins / deficiency*
Cross-Sectional Studies
Pregnancy Complications / blood*
Pyelonephritis / blood*
Young Adult
Grant Support
Z01 HD002400-17/HD/NICHD NIH HHS
Reg. No./Substance:
0/Blood Proteins; 0/plasma protein Z

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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