| Pyelonephritis during pregnancy: a cause for an acquired deficiency of protein Z. | |
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MedLine Citation:
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PMID: 18828054 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Pyelonephritis has a more severe course during pregnancy than in the non-pregnant state. This has been attributed to the increased susceptibility of pregnant women to microbial products. An acquired protein Z deficiency has been reported when there is excessive thrombin activity. The aim of this study was to determine whether pyelonephritis during pregnancy is associated with changes in maternal plasma protein Z concentrations. STUDY DESIGN: A cross-sectional study was conducted to compare plasma protein Z concentrations between normal pregnant women (N = 71) and pregnant women with pyelonephritis (N = 42). Protein Z concentrations were measured by enzyme-linked immunosorbent assay. Parametric and non-parametric statistics were used for analysis. RESULTS: Patients with pyelonephritis had a significantly lower median plasma concentration of protein Z than did patients with normal pregnancies (median 2.14 microg/mL (0.4-3.4) vs. median 2.36 microg/mL (1.09-3.36); p = 0.03). There was no difference in the median plasma concentration of anti-protein Z antibodies between patients with pyelonephritis and those with normal pregnancies. CONCLUSION: The median maternal plasma protein Z concentration was significantly lower in patients with pyelonephritis during pregnancy than in patients with normal pregnancies. |
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Authors:
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Jyh Kae Nien; Roberto Romero; Debra Hoppensteadt; Offer Erez; Jimmy Espinoza; Eleazar Soto; Juan Pedro Kusanovic; Francesca Gotsch; Chong Jai Kim; Pooja Mittal; Jawed Fareed; Joaquin Santolaya; Tinnakorn Chaiworapongsa; Samuel Edwin; Beth Pineles; Sonia Hassan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Volume: 21 ISSN: 1476-4954 ISO Abbreviation: J. Matern. Fetal. Neonatal. Med. Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-10-01 Completed Date: 2009-01-22 Revised Date: 2013-06-05 |
Medline Journal Info:
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Nlm Unique ID: 101136916 Medline TA: J Matern Fetal Neonatal Med Country: United States |
Other Details:
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Languages: eng Pagination: 629-37 Citation Subset: IM |
Affiliation:
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Perinatology Research Branch, NICHD, NIH, DHHS, Bethesda, Maryland, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Blood Proteins / deficiency* Cross-Sectional Studies Female Humans Pregnancy Pregnancy Complications / blood* Pyelonephritis / blood* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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Z01 HD002400-17/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Proteins; 0/plasma protein Z |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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