| Putting the pH into phosphatidic acid signaling. | |
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MedLine Citation:
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PMID: 22136116 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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ABSTRACT: The lipid phosphatidic acid (PA) has important roles in cell signaling and metabolic regulation in all organisms. New evidence indicates that PA also has an unprecedented role as a pH biosensor, coupling changes in pH to intracellular signaling pathways. pH sensing is a property of the phosphomonoester headgroup of PA. A number of other potent signaling lipids also contain headgroups with phosphomonoesters, implying that pH sensing by lipids may be widespread in biology. |
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Authors:
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John Jh Shin; Christopher Jr Loewen |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-2 |
Journal Detail:
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Title: BMC biology Volume: 9 ISSN: 1741-7007 ISO Abbreviation: - Publication Date: 2011 |
Date Detail:
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Created Date: 2011-12-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101190720 Medline TA: BMC Biol Country: - |
Other Details:
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Languages: ENG Pagination: 85 Citation Subset: - |
Affiliation:
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Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, Canada, V6T 1Z3. christopher.loewen@ubc.ca. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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