Document Detail

Putting the pH into phosphatidic acid signaling.
MedLine Citation:
PMID:  22136116     Owner:  NLM     Status:  MEDLINE    
The lipid phosphatidic acid (PA) has important roles in cell signaling and metabolic regulation in all organisms. New evidence indicates that PA also has an unprecedented role as a pH biosensor, coupling changes in pH to intracellular signaling pathways. pH sensing is a property of the phosphomonoester headgroup of PA. A number of other potent signaling lipids also contain headgroups with phosphomonoesters, implying that pH sensing by lipids may be widespread in biology.
John J H Shin; Christopher J R Loewen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2011-12-02
Journal Detail:
Title:  BMC biology     Volume:  9     ISSN:  1741-7007     ISO Abbreviation:  BMC Biol.     Publication Date:  2011  
Date Detail:
Created Date:  2011-12-05     Completed Date:  2012-03-20     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  101190720     Medline TA:  BMC Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  85     Citation Subset:  IM    
Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, Canada, V6T 1Z3.
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MeSH Terms
Hydrogen-Ion Concentration
Phosphatidic Acids / chemistry,  metabolism*
Proteins / metabolism
Signal Transduction
Grant Support
//Canadian Institutes of Health Research
Reg. No./Substance:
0/Phosphatidic Acids; 0/Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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