Document Detail

Putative role of epithelial derived factors in airway smooth muscle reactivity.
MedLine Citation:
PMID:  2080759     Owner:  NLM     Status:  MEDLINE    
Until recently the contractile actions of asthma mediators have been examined in vitro without consideration of the modulatory role of the associated epithelial cells. Removal of the epithelium in vitro augments contraction and reduces relaxation to several bronchoactive agents and bioassay experiments have shown that the protective effects of the epithelium can be transferred to denuded preparations. It now seems likely that one or more epithelial-associated factors eg EpDRF and PGE2 have a protective role in controlling airway contractility. These findings may be important in asthmatics in vivo since there may be some correlation between epithelial damage/loss and airway hyperreactivity. The identity of EpDRF remains unknown but it does not appear to be a prostanoid and is distinct pharmacologically from EDRF found in blood vessels.
D Raeburn
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Agents and actions. Supplements     Volume:  31     ISSN:  0379-0363     ISO Abbreviation:  Agents Actions Suppl.     Publication Date:  1990  
Date Detail:
Created Date:  1991-04-30     Completed Date:  1991-04-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7801014     Medline TA:  Agents Actions Suppl     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  259-74     Citation Subset:  IM    
Rhone-Poulenc (UK) Ltd., Dagenham Research Centre, Essex, England.
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MeSH Terms
Asthma / physiopathology
Biological Factors / metabolism,  physiology
Bronchoconstriction / physiology
Eosinophils / physiology
Epithelium / metabolism,  physiology,  physiopathology
Histological Techniques
Muscle, Smooth / physiology*
Prostaglandins / physiology
Respiratory Physiological Phenomena*
Respiratory System / metabolism,  physiopathology
Reg. No./Substance:
0/Biological Factors; 0/Prostaglandins; 114899-31-9/epithelium-derived relaxant factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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