| Putative mechanisms of cognitive dysfunction in chemotherapy-naïve diffuse large B-cell lymphoma: a case report and review of the literature. | |
| | |
MedLine Citation:
|
PMID: 20799114 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Cognitive impairment is now recognized as a frequent consequence of treatments for cancers localized outside the central nervous system (CNS). In contrast, little attention has been given to the potentially deleterious cognitive effects from non-CNS cancers themselves. The present case study proposes that cognitive deficits occur in a subset of treatment-naive patients with diffuse large B-cell lymphoma in whom no gross evidence of lymphoma-related CNS involvement is apparent. Evidence is presented from a case study and elaborate putative mechanisms centering on deleterious effects of B-cell-mediated inflammatory cytokine secretion on neurons. Moreover, this case study speculates that genetic variability involving apolipoprotein E or other factors may mediate cognitive variability among these patients. |
| | |
Authors:
|
Steven P Cercy; Brian Bronson |
Related Documents
:
|
10412344 - A case of primary bilateral adrenal lymphoma with partial adrenal insufficiency. 3047044 - An unusual morphological variant of follicular lymphoma. report of two cases. 2263844 - Primary extranodal non-hodgkin's lymphoma of the extrahepatic biliary tract. 9267754 - Malignant atrophic papulosis. 16859554 - Postictal psychosis: presymptomatic risk factors and the need for further investigation... 15074344 - Onychotillomania: 2 case reports. |
Publication Detail:
|
Type: Case Reports; Journal Article; Review |
Journal Detail:
|
Title: Applied neuropsychology Volume: 17 ISSN: 1532-4826 ISO Abbreviation: Appl Neuropsychol Publication Date: 2010 Jul |
Date Detail:
|
Created Date: 2010-08-27 Completed Date: 2010-12-13 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9507620 Medline TA: Appl Neuropsychol Country: United States |
Other Details:
|
Languages: eng Pagination: 223-33 Citation Subset: IM |
Affiliation:
|
Mental Health Service, Veterans Affairs New York Harbor Healthcare System, 423 East 23rd Street, New York, NY 10010, USA. steven.cercy@va.gov |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Apolipoproteins E
/
genetics,
physiology B-Lymphocytes / physiology Brain / pathology Cognition Disorders / etiology*, genetics, immunology, pathology Cytokines / physiology Genotype Humans Inflammation / pathology Lymphoma, Large B-Cell, Diffuse / complications, genetics, pathology, psychology* Magnetic Resonance Imaging Male Middle Aged Neuropsychological Tests Polymorphism, Genetic / physiology |
| Chemical | |
Reg. No./Substance:
|
0/Apolipoproteins E; 0/Cytokines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Notation of professional qualifications and affiliations: avoiding puffery and deception.
Next Document: InfarctSizer: computing infarct volume from brain images of a stroke animal model.