Document Detail

Putative mechanisms of cognitive dysfunction in chemotherapy-naïve diffuse large B-cell lymphoma: a case report and review of the literature.
MedLine Citation:
PMID:  20799114     Owner:  NLM     Status:  MEDLINE    
Cognitive impairment is now recognized as a frequent consequence of treatments for cancers localized outside the central nervous system (CNS). In contrast, little attention has been given to the potentially deleterious cognitive effects from non-CNS cancers themselves. The present case study proposes that cognitive deficits occur in a subset of treatment-naive patients with diffuse large B-cell lymphoma in whom no gross evidence of lymphoma-related CNS involvement is apparent. Evidence is presented from a case study and elaborate putative mechanisms centering on deleterious effects of B-cell-mediated inflammatory cytokine secretion on neurons. Moreover, this case study speculates that genetic variability involving apolipoprotein E or other factors may mediate cognitive variability among these patients.
Steven P Cercy; Brian Bronson
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Applied neuropsychology     Volume:  17     ISSN:  1532-4826     ISO Abbreviation:  Appl Neuropsychol     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-08-27     Completed Date:  2010-12-13     Revised Date:  2014-05-02    
Medline Journal Info:
Nlm Unique ID:  9507620     Medline TA:  Appl Neuropsychol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  223-33     Citation Subset:  IM    
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MeSH Terms
Apolipoproteins E / genetics,  physiology
B-Lymphocytes / physiology
Brain / pathology
Cognition Disorders / etiology*,  genetics,  immunology,  pathology
Cytokines / physiology
Inflammation / pathology
Lymphoma, Large B-Cell, Diffuse / complications,  genetics,  pathology,  psychology*
Magnetic Resonance Imaging
Middle Aged
Neuropsychological Tests
Polymorphism, Genetic / physiology
Reg. No./Substance:
0/Apolipoproteins E; 0/Cytokines

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