| Putative factors that may modulate the effect of exercise on liver fat: insights from animal studies. | |
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MedLine Citation:
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PMID: 21912741 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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An increase in intrahepatic triglyceride (IHTG) content is the hallmark of nonalcoholic fatty liver disease (NAFLD) and is strongly associated with insulin resistance and dyslipidemia. Although regular aerobic exercise improves metabolic function, its role in regulating fat accumulation in the liver is incompletely understood, and human data are scarce. Results from exercise training studies in animals highlight a number of potential factors that could possibly mediate the effect of exercise on liver fat, but none of them has been formally tested in man. The effect of exercise on IHTG content strongly depends on the background diet, so that exercise is more effective in reducing IHTG under conditions that favor liver fat accretion (e.g., when animals are fed high-fat diets). Concurrent loss of body weight or visceral fat does not appear to mediate the effect of exercise on IHTG, whereas sex (males versus females), prandial status (fasted versus fed), and duration of training, as well as the time elapsed from the last bout of exercise could all be affecting the observed exercise-induced changes in IHTG content. The potential importance of these factors remains obscure, thus providing a wide array of opportunities for future research on the effects of exercise (and diet) on liver fat accumulation. |
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Authors:
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Faidon Magkos |
Publication Detail:
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Type: Journal Article Date: 2011-09-08 |
Journal Detail:
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Title: Journal of nutrition and metabolism Volume: 2012 ISSN: 2090-0732 ISO Abbreviation: J Nutr Metab Publication Date: 2012 |
Date Detail:
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Created Date: 2011-09-13 Completed Date: 2011-11-10 Revised Date: 2012-04-26 |
Medline Journal Info:
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Nlm Unique ID: 101526296 Medline TA: J Nutr Metab Country: United States |
Other Details:
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Languages: eng Pagination: 827417 Citation Subset: - |
Affiliation:
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Department of Nutrition and Dietetics, Harokopio University, 17671 Athens, Greece. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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