| Putative endothelial progenitor cells are associated with flow-mediated dilation in refractory hypertensives. | |
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MedLine Citation:
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PMID: 19085535 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Hypertension has been related to endothelial dysfunction. Patients with refractory hypertension (RH) have a reduced number of endothelial progenitor cells (EPCs). AIM: To evaluate if blood EPC levels relate to endothelium-dependent vasodilation (ED-VD) in RH. METHODS: We analyzed 29 RH confirmed by 24-h ambulatory blood pressure monitoring and assessed complete clinical and laboratory evaluation. EPCs were isolated from peripheral mononuclear cells (MNC) by flow cytometry. ED-VD was determined measuring flow-mediated dilation (FMD) by venous occlusion plethysmography. Results. Circulating EPCs/10(5) MNC (median [Q1-Q3]): 23.0 [4.5-53.8]. FMD (median [Q1-Q3]): 211.7 [79.5-365.8]%. Significant correlations with log-FMD: EPCs (r = 0.469; p = 0.018) and homocysteine (r = -0.414; p = 0.045). There was no collinearity between EPCs and homocysteine. FMD did not correlate with age, gender, office BP, 24-h systolic blood pressure or 24-h diastolic blood pressure, laboratory parameters, C-reactive-protein, left ventricular-mass index, dyslipidaemia, smoking habit and statin or angiotensin system blockers treatment. Multiple linear regression analysis showed that after age-adjustment, EPC (p = 0.027) and homocysteine (p = 0.004) were the only variables that predicted FMD (R = 0.740). After dividing patients according to EPC number, patients in the lower tertile showed a significantly reduced FMD compared with those in the group of the two upper tertiles of EPC: log-FMD (mean+/-SD): 4.7+/-0.9 vs 5.6+/-0.8, respectively (p = 0.031). CONCLUSIONS: ED-VD independently correlates with circulating EPCs in RH. Homocysteine is also an independent predictor of lower FMD in such patients. |
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Authors:
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Anna Oliveras; Alejandro de la Sierra; Ofelia M Martínez-Estrada; María Larrousse; Susana Vázquez; Maria José Soler; Mercedes Zuasti; Joan S Vila; Manuel Reina; Alex Roca-Cusachs; Josep Lloveras |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Blood pressure Volume: 17 ISSN: 1651-1999 ISO Abbreviation: Blood Press. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-12-16 Completed Date: 2009-02-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9301454 Medline TA: Blood Press Country: Norway |
Other Details:
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Languages: eng Pagination: 298-305 Citation Subset: IM |
Affiliation:
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Hypertension Unit, Nephrology Department, Hospital Universitari del Mar, Universitat Autonoma de Barcelona, Medicine Department, Barcelona, Spain. aoliveras@imas.imim.es |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cell Count Cell Separation Dilatation, Pathologic / diagnosis*, pathology Endothelial Cells / pathology* Flow Cytometry Homocysteine / blood Humans Hypertension / pathology* Middle Aged Predictive Value of Tests Regression Analysis Stem Cells / pathology* Vasodilation |
| Chemical | |
Reg. No./Substance:
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454-28-4/Homocysteine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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