Document Detail

Putative endothelial progenitor cells are associated with flow-mediated dilation in refractory hypertensives.
MedLine Citation:
PMID:  19085535     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Hypertension has been related to endothelial dysfunction. Patients with refractory hypertension (RH) have a reduced number of endothelial progenitor cells (EPCs). AIM: To evaluate if blood EPC levels relate to endothelium-dependent vasodilation (ED-VD) in RH. METHODS: We analyzed 29 RH confirmed by 24-h ambulatory blood pressure monitoring and assessed complete clinical and laboratory evaluation. EPCs were isolated from peripheral mononuclear cells (MNC) by flow cytometry. ED-VD was determined measuring flow-mediated dilation (FMD) by venous occlusion plethysmography. Results. Circulating EPCs/10(5) MNC (median [Q1-Q3]): 23.0 [4.5-53.8]. FMD (median [Q1-Q3]): 211.7 [79.5-365.8]%. Significant correlations with log-FMD: EPCs (r = 0.469; p = 0.018) and homocysteine (r = -0.414; p = 0.045). There was no collinearity between EPCs and homocysteine. FMD did not correlate with age, gender, office BP, 24-h systolic blood pressure or 24-h diastolic blood pressure, laboratory parameters, C-reactive-protein, left ventricular-mass index, dyslipidaemia, smoking habit and statin or angiotensin system blockers treatment. Multiple linear regression analysis showed that after age-adjustment, EPC (p = 0.027) and homocysteine (p = 0.004) were the only variables that predicted FMD (R = 0.740). After dividing patients according to EPC number, patients in the lower tertile showed a significantly reduced FMD compared with those in the group of the two upper tertiles of EPC: log-FMD (mean+/-SD): 4.7+/-0.9 vs 5.6+/-0.8, respectively (p = 0.031). CONCLUSIONS: ED-VD independently correlates with circulating EPCs in RH. Homocysteine is also an independent predictor of lower FMD in such patients.
Anna Oliveras; Alejandro de la Sierra; Ofelia M Martínez-Estrada; María Larrousse; Susana Vázquez; Maria José Soler; Mercedes Zuasti; Joan S Vila; Manuel Reina; Alex Roca-Cusachs; Josep Lloveras
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Blood pressure     Volume:  17     ISSN:  1651-1999     ISO Abbreviation:  Blood Press.     Publication Date:  2008  
Date Detail:
Created Date:  2008-12-16     Completed Date:  2009-02-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9301454     Medline TA:  Blood Press     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  298-305     Citation Subset:  IM    
Hypertension Unit, Nephrology Department, Hospital Universitari del Mar, Universitat Autonoma de Barcelona, Medicine Department, Barcelona, Spain.
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MeSH Terms
Cell Count
Cell Separation
Dilatation, Pathologic / diagnosis*,  pathology
Endothelial Cells / pathology*
Flow Cytometry
Homocysteine / blood
Hypertension / pathology*
Middle Aged
Predictive Value of Tests
Regression Analysis
Stem Cells / pathology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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