Document Detail

Putative effects of endocrine disrupters on pubertal development in the human.
MedLine Citation:
PMID:  11987902     Owner:  NLM     Status:  MEDLINE    
Pubertal development is regulated by gonadotrophins and sex hormones. There has been a clear secular trend in the timing of puberty during the last century, puberty becoming earlier. Although improved nutrition is assumed to be the cause, this could partly be associated with exposure to so-called endocrine disrupters. Precocious puberty has been described in several case reports of accidental exposure to oestrogenic compounds in cosmetic products, food and pharmaceuticals. Local epidemics of premature thelarche have also been suggested to be linked to endocrine disrupters. Children adopted from developing countries to industrialized countries often develop precocious puberty. Not only precocious puberty, but also delayed puberty can, theoretically, be associated with exposure to endocrine disrupters. While it is very plausible that endocrine disrupters may disturb pubertal development, there is very little research on this and, therefore, we do not yet have any clear cause-effect relationships in humans.
Grete Teilmann; Anders Juul; Niels E Skakkebaek; Jorma Toppari
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Best practice & research. Clinical endocrinology & metabolism     Volume:  16     ISSN:  1521-690X     ISO Abbreviation:  Best Pract. Res. Clin. Endocrinol. Metab.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-05-03     Completed Date:  2002-05-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101120682     Medline TA:  Best Pract Res Clin Endocrinol Metab     Country:  England    
Other Details:
Languages:  eng     Pagination:  105-21     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Elsevier Science Ltd.
Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet Blegdamsvej 9, 2100 Copenhagen Ø, Denmark.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Endocrine Glands / drug effects*
Estrogens / pharmacology
Estrogens, Non-Steroidal / pharmacology
Plant Preparations
Puberty / drug effects*
Puberty, Delayed / chemically induced
Puberty, Precocious / chemically induced,  psychology
Reg. No./Substance:
0/Estrogens; 0/Estrogens, Non-Steroidal; 0/Isoflavones; 0/Phytoestrogens; 0/Plant Preparations

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Disturbance of pubertal development after cancer treatment.
Next Document:  The role of mutations affecting gonadotrophin secretion and action in disorders of pubertal developm...