| Putative effects of endocrine disrupters on pubertal development in the human. | |
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MedLine Citation:
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PMID: 11987902 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pubertal development is regulated by gonadotrophins and sex hormones. There has been a clear secular trend in the timing of puberty during the last century, puberty becoming earlier. Although improved nutrition is assumed to be the cause, this could partly be associated with exposure to so-called endocrine disrupters. Precocious puberty has been described in several case reports of accidental exposure to oestrogenic compounds in cosmetic products, food and pharmaceuticals. Local epidemics of premature thelarche have also been suggested to be linked to endocrine disrupters. Children adopted from developing countries to industrialized countries often develop precocious puberty. Not only precocious puberty, but also delayed puberty can, theoretically, be associated with exposure to endocrine disrupters. While it is very plausible that endocrine disrupters may disturb pubertal development, there is very little research on this and, therefore, we do not yet have any clear cause-effect relationships in humans. |
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Authors:
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Grete Teilmann; Anders Juul; Niels E Skakkebaek; Jorma Toppari |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Best practice & research. Clinical endocrinology & metabolism Volume: 16 ISSN: 1521-690X ISO Abbreviation: Best Pract. Res. Clin. Endocrinol. Metab. Publication Date: 2002 Mar |
Date Detail:
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Created Date: 2002-05-03 Completed Date: 2002-05-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101120682 Medline TA: Best Pract Res Clin Endocrinol Metab Country: England |
Other Details:
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Languages: eng Pagination: 105-21 Citation Subset: IM |
Copyright Information:
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Copyright 2002 Elsevier Science Ltd. |
Affiliation:
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Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet Blegdamsvej 9, 2100 Copenhagen Ø, Denmark. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adoption Child Diet Endocrine Glands / drug effects* Estrogens / pharmacology Estrogens, Non-Steroidal / pharmacology Female Humans Isoflavones* Male Phytoestrogens Plant Preparations Pregnancy Puberty / drug effects* Puberty, Delayed / chemically induced Puberty, Precocious / chemically induced, psychology |
| Chemical | |
Reg. No./Substance:
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0/Estrogens; 0/Estrogens, Non-Steroidal; 0/Isoflavones; 0/Phytoestrogens; 0/Plant Preparations |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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