| PURTSCHER RETINOPATHY: AN ALTERNATIVE ETIOLOGY SUPPORTED BY COMPUTER FLUID DYNAMIC SIMULATIONS. | |
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MedLine Citation:
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PMID: 21908582 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Purpose:To explore an alternative etiology for Purtscher retinopathy by literature review and fluid dynamic computational simulations of wall shear stress profiles.Methods:Computer simulations were developed, incorporating posterior pole retinal microvascular flow parameters, to demonstrate wall shear stress profiles at ninety and forty-five degree angle artery/arteriolar branching.Results:Computer simulations reveal wall shear stress profiles dependent on artery/arteriolar branching angles. At high flow rates an area of changed wall shear stress and flow swirling and reversal was noted at the proximal fillet of the ninety degree arteriolar branching. These changes did not appear at the forty-five degree arteriolar branching until flow rate was increased an additional thirty percentConclusion:Computer simulation data, as well as review of the history and clinical findings of Purtscher and Purtscher-like retinopathy, present evidence that an additional etiology for Purtscher retinopathy may be a rheological event at a retinal posterior pole foci of vascular endothelial dysregulation, followed by downstream endothelin induced vasculopathy. |
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Authors:
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Thomas J Harrison; Cyrus O Abbasi; Tariq A Khraishi |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-9 |
Journal Detail:
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Title: Investigative ophthalmology & visual science Volume: - ISSN: 1552-5783 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1301 Vista Morada, Santa Fe, NM 87506 USA, e-mail: tom_harrison3@hotmail.com, Phone:(505) 983-9283, FAX: (505) 982-6362. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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