Document Detail


Purpurogallin--a natural and effective hepatoprotector in vitro and in vivo.
MedLine Citation:
PMID:  1799443     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Purpurogallin is a plant phenol that is sometimes added as an oxidation retardant to fats-oils or to certain fuels or lubricants. However, it was unknown if purpurogallin is cytoprotective. Here we examined this issue, both in isolated hepatocytes and in vivo. From 0.5 to 2.0 mM, purpurogallin prolongs survival of rat hepatocytes substantially against oxyradicals generated with xanthine oxidase and hypoxanthine. The protection was dose dependent and surpassed that given by such antioxidants as ascorbate, mannitol, superoxide dismutase, catalase, and Trolox, when each was examined at or near its optimal concentration in the same system. When 1.5, 3, and 6 mumol of purpurogallin in saline were infused into rats with postischemic livers shortly before reperfusion, the mean hepatic salvages were 42, 76, and 86%, respectively. Such salvage effects would rank purpurogallin highly among the hepatoprotectors known. Over the range of 31 to 500 microM, purpurogallin inhibited the rate of O2 consumption in the xanthine oxidase reaction by approximately 90%, which was 2- to several-fold higher than the inhibition elicited by allopurinol over the same concentrations. Thus, purpurogallin is an effective natural hepatoprotector that may operate partly or principally as an inhibitor of xanthine oxidase.
Authors:
T W Wu; L H Zeng; J Wu; D Carey
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemistry and cell biology = Biochimie et biologie cellulaire     Volume:  69     ISSN:  0829-8211     ISO Abbreviation:  Biochem. Cell Biol.     Publication Date:    1991 Oct-Nov
Date Detail:
Created Date:  1992-04-23     Completed Date:  1992-04-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8606068     Medline TA:  Biochem Cell Biol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  747-50     Citation Subset:  IM; S    
Affiliation:
Department of Clinical Biochemistry, University of Toronto, Canada.
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MeSH Terms
Descriptor/Qualifier:
Allopurinol / pharmacology
Animals
Antioxidants / pharmacology
Benzocycloheptenes / pharmacology*
Free Radicals / toxicity
Infusions, Intravenous
Liver / drug effects,  pathology*
Male
Necrosis
Oxygen / toxicity*
Rats
Rats, Inbred Strains
Reperfusion Injury / drug therapy*
Xanthine Oxidase / drug effects
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Benzocycloheptenes; 0/Free Radicals; 315-30-0/Allopurinol; 569-77-7/purpurogallin; 7782-44-7/Oxygen; EC 1.17.3.2/Xanthine Oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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