Document Detail

Purpura fulminans in a newborn infant with galactosemia.
MedLine Citation:
PMID:  20016915     Owner:  NLM     Status:  MEDLINE    
An 11-day-old neonate presented with purpura fulminans and was subsequently diagnosed with galactosemia. Neonatal purpura fulminans occurs predominantly in patients suffering from inherited protein C deficiency or disseminated intravascular coagulation associated with septicemia. Hemostatic changes in patients with liver disease may result in bleeding or, rarely, thrombosis. We suppose that in the present patient, deficiency of protein C, secondary to liver disease, was responsible for the development of purpura fulminans. Treatment consisted of blood and blood products and galactose-free formula. The patient recovered with residual mild psychomotor retardation and the lesions with minimal scarring. In conclusion, galactosemia also should be kept in mind as an uncommon cause of purpura fulminans in newborn infants.
Aysegul Zenciroglu; Mehmet Sah Ipek; Mustafa Aydin; Abdurrahman Kara; Nurullah Okumus; Mustafa Kilic
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-12-17
Journal Detail:
Title:  European journal of pediatrics     Volume:  169     ISSN:  1432-1076     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-05-26     Completed Date:  2010-09-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  903-6     Citation Subset:  IM    
Division of Neonatology, Department of Pediatrics, Dr. Sami Ulus Maternity and Children's Hospital, Babur Street, No: 44, Altindag, 06080, Ankara, Turkey.
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MeSH Terms
Galactosemias / complications*,  genetics,  metabolism
Infant, Newborn
Methylenetetrahydrofolate Reductase (NADPH2) / genetics
Protein C / metabolism
Purpura Fulminans / etiology*
Reg. No./Substance:
0/Protein C; EC Reductase (NADPH2)

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