Document Detail

Purpura Fulminans Associated with Streptococcus pneumoniae Septicemia in an Asplenic Pediatric Patient.
MedLine Citation:
PMID:  23985086     Owner:  NLM     Status:  In-Data-Review    
Purpura fulminans is a rapidly progressive syndrome of small-vessel thrombosis and hemorrhagic necrosis of the skin accompanied by disseminated intravascular coagulation. We describe a case of Streptococcus pneumoniae septicemia in an asplenic 5-year-old boy on oral tacrolimus, with a past medical history of multivisceral organ transplantation and subsequent development of purpura fulminans on his chest and distal extremities. The acute infectious form of purpura fulminans is usually caused by gram-negative bacteria. Cases secondary to gram-positive encapsulated bacteria usually occur when individuals are immuno-suppressed or have anatomic or functional asplenia. Our patient had both, which likely increased his susceptibility, and he responded well to antimicrobial therapy in addition to prophylactic coverage in the setting of his immunosuppression. We review the literature for similar cases due to S. pneumoniae in the pediatric population and discuss the etiology and treatment of purpura fulminans.
S Konda; D Zell; C Milikowski; J Alonso-Llamazares
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Actas dermo-sifiliográficas     Volume:  104     ISSN:  1578-2190     ISO Abbreviation:  Actas Dermosifiliogr     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-08-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0373062     Medline TA:  Actas Dermosifiliogr     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  623-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier España, S.L. and AEDV. All rights reserved.
Department of Dermatology, Howard University College of Medicine, Washington, DC, United States.
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