Document Detail

Puromycin-sensitive aminopeptidase is essential for the maternal recognition of pregnancy in mice.
MedLine Citation:
PMID:  11376108     Owner:  NLM     Status:  MEDLINE    
Maternal recognition of pregnancy in rodents requires semicircadian surges of hypophyseal PRL secretion during early gestation, which are required for the formation of the corpus luteum of pregnancy (CLP). Here we show that puromycin-sensitive aminopeptidase (Psa)-deficient mice display female infertility that results from impaired formation of CLP. Transplantation of mutant ovaries into normal females restored fertility but not vice versa. Psa-deficient females revealed no semicircadian surges of PRL induced after mating stimuli. Pregnancy in the mutant females was restored by grafting intact pituitaries to elevate circulating levels of PRL. Psa is thus required for the appearance of the semicircadian surges of PRL secretion that are crucial for maintaining pregnancy in rodents.
T Osada; G Watanabe; Y Sakaki; T Takeuchi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Molecular endocrinology (Baltimore, Md.)     Volume:  15     ISSN:  0888-8809     ISO Abbreviation:  Mol. Endocrinol.     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-05-28     Completed Date:  2001-08-16     Revised Date:  2007-03-27    
Medline Journal Info:
Nlm Unique ID:  8801431     Medline TA:  Mol Endocrinol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  882-93     Citation Subset:  IM    
Mitsubishi Kasei Institute of Life Sciences, 11 Minamiooya, Machida, Tokyo 194-8511, Japan.
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MeSH Terms
Aminopeptidases / deficiency,  genetics,  metabolism*
Cells, Cultured
Circadian Rhythm
Corpus Luteum / physiology*
Dopamine / pharmacology
Embryo Implantation
Estrus / physiology*
Infertility, Female
Mice, Inbred BALB C
Mice, Transgenic
Ovary / transplantation
Pituitary Gland / cytology
Pregnancy, Animal*
Prolactin / administration & dosage,  genetics,  secretion*
Uterus / anatomy & histology
Reg. No./Substance:
9002-62-4/Prolactin; EC 3.4.11.-/Aminopeptidases; EC degrading enzyme

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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