Document Detail


Purity determination and uncertainty evaluation of folic acid by mass balance method.
MedLine Citation:
PMID:  23158297     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Folic acid is one of the most important nutrient substances for human beings, especially for the pregnant women and infants. Therefore the purity determination of folic acid is particularly important. The mass balance method was employed to determine the purity of folic acid, by using the measures of high performance liquid chromatography (HPLC), Karl Fischer titration and other conventional approach. The moisture quantification of folic acid was a major problem since it is a thermally unstable substance and it is apt to contain crystal water. Therefore, a novel improved Karl Fischer method was established for accurate determination of the water content in folic acid, whose repeatability (RSD=2.9%) was significantly better than that of the original direct injection method (RSD=12%). The purity of folic acid certified reference material (CRM) determined by mass balance method was 90.9% with an expanded uncertainty of 0.35%, and the content of water (the major impurity) was 8.5%, with an expanded uncertainty of 0.32%.
Authors:
Hui Gong; Ting Huang; Yi Yang; Haifeng Wang
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Publication Detail:
Type:  Journal Article     Date:  2012-09-15
Journal Detail:
Title:  Talanta     Volume:  101     ISSN:  1873-3573     ISO Abbreviation:  Talanta     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2984816R     Medline TA:  Talanta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  96-103     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Affiliation:
College of Science, Beijing University of Chemical Technology, Beijing 100029, China.
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