Document Detail

Purines and oxypurines in myocardial ischemia.
MedLine Citation:
PMID:  19198717     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the plasma levels of purine nucleosides and oxypurines in the presence of other risk factors as additional markers for the diagnosis of myocardial ischemia and severity of myocardial infarction. METHODS: A case control study was conducted on 101 patients with ischemic heart disease (stable angina, n=19: unstable angina, n=29: acute myocardial infarction [AMI]; n=53 patients) admitted to the Cardiology Unit at Al-Kadhimyia Teaching Hospital, Baghdad, Iraq from January to November 2007 in addition to 31 healthy controls. Blood samples were aspirated from those with AMI within the first 12 hours of onset of chest pain. Plasma adenosine (ADO), inosine (INO), hypoxanthine (HYP), and xanthine (XAN) were analyzed by high-performance liquid chromatography. RESULTS: The mean plasma ADO, INO, HYP, and XAN levels were raised in unstable angina over the control values. More increase in all nucleosides and oxypurines was reported in the plasma of patients with AMI as compared to the controls and those of stable angina. The INO (p=0.01) and HYP (p=0.001) values were increased significantly in diabetic men with AMI and at age of < or = 54 years. The mean uric acid values were significantly elevated in hypertensives with unstable angina and smokers with stable angina. CONCLUSION: The levels of purines and their catabolites could be used as additional indices for prior or current ischemia. Pretreatment with such nucleosides, or their oxypurine derivatives, is suggested to improve the regional ventricular function after coronary artery occlusion.
Salwa A Al-Shamiri; Najat A Hasan; William M Frankul; Ammar T Al-Hamdi
Related Documents :
7594077 - Dynamic on-line vectorcardiography improves and simplifies in-hospital ischemia monitor...
10325977 - Consumption of vitamin e in coronary circulation in patients with variant angina.
12230027 - The effect of acupuncture on the coronary arteries as evaluated by coronary angiography...
15234407 - The angiographic and clinical benefits of mibefradil in the coronary slow flow phenomenon.
32987 - The effect of established beta-adrenoreceptor-blocking therapy on the release of cytoso...
9486267 - Myocardial adenosine a1-receptor sensitivity during juvenile and adult stages of matura...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Saudi medical journal     Volume:  30     ISSN:  0379-5284     ISO Abbreviation:  Saudi Med J     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-09     Completed Date:  2009-05-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909441     Medline TA:  Saudi Med J     Country:  Saudi Arabia    
Other Details:
Languages:  eng     Pagination:  257-66     Citation Subset:  IM    
Department of Physiological Chemistry, University of Baghdad, Baghdad, Iraq.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Middle Aged
Myocardial Ischemia / blood*
Purine Nucleosides / blood*,  metabolism*
Reg. No./Substance:
0/Purine Nucleosides; 0/Purines; 120-73-0/purine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Hematological indices in human immunodeficiency virus and pulmonary tuberculosis infections in parts...
Next Document:  Acute post cessation smoking. A strong predictive factor for metabolic syndrome among adult Saudis.