Document Detail

Purinergic trophic signalling in glial cells: functional effects and modulation of cell proliferation, differentiation, and death.
MedLine Citation:
PMID:  22528683     Owner:  NLM     Status:  MEDLINE    
In the last decades, the discovery that glial cells do not only fill in the empty space among neurons or furnish them with trophic support but are rather essential participants to the various activities of the central and peripheral nervous system has fostered the search for the signalling pathways controlling their functions. Since the early 1990s, purines were foreseen as some of the most promising candidate molecules. Originally just a hypothesis, this has become a certainty as experimental evidence accumulated over years, as demonstrated by the exponentially growing number of articles related to the role of extracellular nucleotides and nucleosides in controlling glial cell functions. Indeed, as new functions for already known glial cells (for example, the ability of parenchymal astrocytes to behave as stem cells) or new subtypes of glial cells (for example, NG2(+) cells, also called polydendrocytes) are discovered also, new actions and new targets for the purinergic system are identified. Thus, glial purinergic receptors have emerged as new possible pharmacological targets for various acute and chronic pathologies, such as stroke, traumatic brain and spinal cord injury, demyelinating diseases, trigeminal pain and migraine, and retinopathies. In this article, we will summarize the most important and promising actions mediated by extracellular purines and pyrimidines in controlling the functions, survival, and differentiation of the various "classical" types of glial cells (i.e., astrocytes, oligodendrocytes, microglial cells, Müller cells, satellite glial cells, and enteric glial cells) but also of some rather new members of the family (e.g., polydendrocytes) and of other cells somehow related to glial cells (e.g., pericytes and spinal cord ependymal cells).
Davide Lecca; Stefania Ceruti; Marta Fumagalli; Maria P Abbracchio
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-04-12
Journal Detail:
Title:  Purinergic signalling     Volume:  8     ISSN:  1573-9546     ISO Abbreviation:  Purinergic Signal.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-05-25     Completed Date:  2013-02-08     Revised Date:  2014-08-04    
Medline Journal Info:
Nlm Unique ID:  101250499     Medline TA:  Purinergic Signal     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  539-57     Citation Subset:  IM    
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MeSH Terms
Astrocytes / physiology
Cell Death / physiology*
Cell Differentiation / physiology*
Cell Proliferation*
Microglia / physiology
Neuroglia / physiology*
Oligodendroglia / physiology
Receptors, Purinergic / physiology*
Retina / cytology,  physiology
Schwann Cells / physiology
Signal Transduction / physiology*
Grant Support
GGP09128//Telethon; GGP10082//Telethon
Reg. No./Substance:
0/Receptors, Purinergic

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