Document Detail

Purinergic signaling in hypothalamic tanycytes: potential roles in chemosensing.
MedLine Citation:
PMID:  21396904     Owner:  NLM     Status:  MEDLINE    
Hypothalamic tanycytes are cells that line the walls of the 3rd ventricle. Their cell bodies contact the cerebrospinal fluid and give rise to an inwardly directed process. The more dorsally located (α1 and α2) tanycytes project to areas of the brain involved in the control of feeding and energy balance (the arcuate nucleus and ventromedial hypothalamic nucleus). Although their functions are poorly understood, they have some similarities to glial cells. Recent evidence shows that they express key molecules involved in purinergic signaling and at least some tanycytes may act as adult multipotent stem cells. Emerging evidence suggests that tanycytes signal through changes in intracellular Ca(2+) and that they can respond with large Ca(2+) signals to ATP and transmitters associated with wakefulness and the drive to feed. They are also glucosensitive and this response is dependent on release of ATP from tanycytes and the activation of P2Y1 receptors. Their ability to release ATP gives potential for their integration into the hypothalamic circuitry controlling energy balance and feeding, but many fundamental questions about their possible functions and roles remain unanswered.
Nicholas Dale
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2011-03-21
Journal Detail:
Title:  Seminars in cell & developmental biology     Volume:  22     ISSN:  1096-3634     ISO Abbreviation:  Semin. Cell Dev. Biol.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-04     Completed Date:  2011-07-11     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  9607332     Medline TA:  Semin Cell Dev Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  237-44     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
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MeSH Terms
Adenosine Triphosphate / metabolism
Glucose / metabolism
Hypothalamus / metabolism*
Receptors, Purinergic / metabolism*
Signal Transduction*
Grant Support
G0601748//Medical Research Council; //Medical Research Council
Reg. No./Substance:
0/Receptors, Purinergic; 8L70Q75FXE/Adenosine Triphosphate; IY9XDZ35W2/Glucose

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