| Purinergic signaling in giant cell formation. | |
| | |
MedLine Citation:
|
PMID: 22201854 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Cell fusion into multinucleated giant cells (MGC) is an essential process that contributes to many important biological mechanisms in mammalians. In the bone and immune system, macrophages are endowed with a remarkable potential for cell fusion events as evidenced by their propensity to fuse with other cells and between themselves during both normal processes and disease. Macrophage fusion is critical for the normal development of multinucleated osteoclasts, the cells responsible for bone resorption. Macrophages from various tissue compartments also undergo fusion into MGC, a hallmark of granulomatous inflammation. To date, the mechanisms underlying macrophage fusion remain poorly understood. Receptor-ligand interactions are thought to mediate this process and several lines of evidence implicate purinergic receptors in both osteoclast and MGC formation. Notably, the P2X7 receptor for extracellular ATP is expressed in osteoclasts and in many types of granulomas associated with infection, foreign body response and sterile inflammation. Through their ability to sense extracellular cues and ATP, a messenger of intercellular communication, purinergic receptors likely contribute to cell-cell interactions that result in macrophage fusion. |
| | |
Authors:
|
Irma Lemaire; Simonetta Falzoni; Elena Adinolfi |
Related Documents
:
|
18220804 - Porphyromonas gingivalis mediated periodontal disease and atherosclerosis: disparate di... 20922084 - Nicotine and periodontal tissues. 19473524 - Porphyromonas gingivalis induce apoptosis in human gingival epithelial cells through a ... 19201894 - Critical role of apoptotic speck protein containing a caspase recruitment domain (asc) ... 20954074 - Cytoprotective effects of triphlorethol-a against formaldehyde-induced oxidative damage... 11865704 - Th1-like and th2-like cytokines in patients undergoing open versus laparascopic cholecy... |
Publication Detail:
|
Type: Journal Article Date: 2012-01-01 |
Journal Detail:
|
Title: Frontiers in bioscience (Elite edition) Volume: 4 ISSN: 1945-0508 ISO Abbreviation: Front Biosci (Elite Ed) Publication Date: 2012 |
Date Detail:
|
Created Date: 2011-12-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101485240 Medline TA: Front Biosci (Elite Ed) Country: United States |
Other Details:
|
Languages: eng Pagination: 41-55 Citation Subset: IM |
Affiliation:
|
Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Peritoneal endometriosis is an inflammatory disease.
Next Document: Domestic endotoxin exposure and asthma in children: epidemiological studies.