| Purine seizure disorders. | |
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MedLine Citation:
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PMID: 3698938 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Developing antiepileptic agents that are specifically tailored to a patient's individual biochemistry has long been a goal of neurology. Three patients who had hyperuricosuria combined with a seizure disorder that failed to respond to traditional anticonvulsants are described. The patients had the best control of their seizure disorder when a specific metabolic drug, allopurinol, was used as an anticonvulsant. All three patients had onset of the seizure disorder at 22 months of age, a finding possibly related to maturation of purine enzymes. Because elevated uric acid levels in the immediate postictal period may occur in seizure patients, the presence of an elevated uric acid clearance in seizure-free periods is needed to consider the diagnosis of an allopurinol-responsive seizure problem in any individual patient. In the two patients past the onset of puberty, lowering (one case) and cessation (other case) of the dose of allopurinol has been possible. |
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Authors:
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M Coleman; M Landgrebe; A Landgrebe |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Epilepsia Volume: 27 ISSN: 0013-9580 ISO Abbreviation: Epilepsia Publication Date: 1986 May-Jun |
Date Detail:
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Created Date: 1986-06-24 Completed Date: 1986-06-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2983306R Medline TA: Epilepsia Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 263-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Allopurinol / therapeutic use Child Epilepsy / etiology, metabolism* Humans Male Purines / metabolism* Uric Acid / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Purines; 315-30-0/Allopurinol; 69-93-2/Uric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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