| Purine receptors and kynurenic acid modulate the somatosensory evoked potential in rat cerebral cortex. | |
| | |
MedLine Citation:
|
PMID: 2446838 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Adenosine and analogues, and antagonists to adenosine and putative excitatory amino acid transmitters were topically applied to the cerebral cortex of urethane-anaesthetised rats and their effects on the somatosensory evoked potentials (SEPs) examined. 2-Chloro-adenosine decreased the amplitude of the SEPs whereas adenosine did not. Both L-(-)N6-phenyl-isopropyladenosine (L-PIA) and 5'-N-ethylcarboxamide adenosine (NECA) depressed the SEPs; the effect of L-PIA was more marked than that of NECA. 8-p-Sulphophenyl theophylline increased the amplitude of the SEPs and also inhibited the effects of 2-chloro-adenosine and L-PIA. Kynurenic acid decreased the amplitude of the SEPs. The results suggest that the initial component of the SEP is a post-synaptic event and that endogenous adenosine probably modulates thalamo-cortical synaptic transmission. |
| | |
Authors:
|
J I Addae; T W Stone |
Related Documents
:
|
16110278 - Spinal cord glia activation following peripheral polyinosine-polycytidylic acid adminis... 87248 - Kainic acid-induced neurotoxicity in the striatum: a histofluorescent study. 1479448 - Excitotoxic acid lesions of the primate subthalamic nucleus result in transient dyskine... 10817618 - Neuroprotective potency of kynurenic acid against excitotoxicity. 9774438 - Branched-chain amino acids are essential in the regulation of phas-i and p70 s6 kinase ... 17805628 - Keto fatty acids formcuspidaria pterocarpa seed oil. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Electroencephalography and clinical neurophysiology Volume: 69 ISSN: 0013-4694 ISO Abbreviation: Electroencephalogr Clin Neurophysiol Publication Date: 1988 Feb |
Date Detail:
|
Created Date: 1988-02-18 Completed Date: 1988-02-18 Revised Date: 2010-08-25 |
Medline Journal Info:
|
Nlm Unique ID: 0375035 Medline TA: Electroencephalogr Clin Neurophysiol Country: IRELAND |
Other Details:
|
Languages: eng Pagination: 186-9 Citation Subset: IM |
Affiliation:
|
Department of Physiology, St. George's Hospital Medical School, London, U.K. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
2-Chloroadenosine Adenosine / analogs & derivatives, pharmacology* Adenosine-5'-(N-ethylcarboxamide) Animals Cerebral Cortex / drug effects* Evoked Potentials, Somatosensory / drug effects* Kynurenic Acid / pharmacology* Male Phenylisopropyladenosine / pharmacology Rats Rats, Inbred Strains Receptors, Purinergic / drug effects Synaptic Transmission / drug effects |
| Grant Support | |
ID/Acronym/Agency:
|
//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
|
0/Receptors, Purinergic; 146-77-0/2-Chloroadenosine; 29193-86-0/Phenylisopropyladenosine; 35920-39-9/Adenosine-5'-(N-ethylcarboxamide); 492-27-3/Kynurenic Acid; 58-61-7/Adenosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Recurrent inhibition of firing motoneurones in man.
Next Document: Development of the EEG of school-age children and adolescents. I. Analysis of band power.