Document Detail

Purine nucleotide metabolism in resident and activated rat macrophages in vitro.
MedLine Citation:
PMID:  2408899     Owner:  NLM     Status:  MEDLINE    
The overall purine metabolism was studied in detail in resident peritoneal macrophages (M phi) and in thioglycolate elicited peritoneal M phi in vitro. The salvage of purine bases (adenine, hypoxanthine and guanine) was active in both M phi populations, whereas purine biosynthesis de novo was low. Purine nucleosides (inosine, guanosine and adenosine) were efficiently degraded to uric acid and only adenosine was directly salvaged into nucleotides. Purine salvage was markedly increased in elicited M phi as compared to resident M phi whereas purine degradation pathways were enhanced only slightly. These results clearly indicate that salvage of purine bases is the main source for purine nucleotide biosynthesis in M phi, but nucleotide catabolism is the predominant pathway.
J Barankiewicz; A Cohen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of immunology     Volume:  15     ISSN:  0014-2980     ISO Abbreviation:  Eur. J. Immunol.     Publication Date:  1985 Jun 
Date Detail:
Created Date:  1985-08-07     Completed Date:  1985-08-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1273201     Medline TA:  Eur J Immunol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  627-31     Citation Subset:  IM    
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MeSH Terms
Adenine / metabolism
Adenosine / metabolism
Cells, Cultured
Guanine / metabolism
Guanosine / metabolism
Hypoxanthines / metabolism
Inosine / metabolism
Macrophage Activation* / drug effects
Macrophages / metabolism*
Pentosephosphates / metabolism
Phosphoribosyl Pyrophosphate
Purine Nucleotides / metabolism*
Thioglycolates / pharmacology
Reg. No./Substance:
0/Hypoxanthines; 0/Pentosephosphates; 0/Purine Nucleotides; 0/Thioglycolates; 118-00-3/Guanosine; 58-61-7/Adenosine; 58-63-9/Inosine; 68-94-0/Hypoxanthine; 73-24-5/Adenine; 73-40-5/Guanine; 7540-64-9/Phosphoribosyl Pyrophosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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