Document Detail


Purine metabolism in Saccharomyces cerevisiae.
MedLine Citation:
PMID:  332289     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The synthesis, interconversion, and catabolism of purine bases, ribonucleosides, and ribonucleotides in wild-type Saccharomyces cerevisiae were studied by measuring the conversion of radioactive adenine, hypoxanthine, guanine, and glycine into acid-soluble purine bases, ribonucleosides, and ribonucleotides, and into nucleic acid adenine and guanine. The pathway(s) by which adenine is converted to inosinate is (are) uncertain. Guanine is extensively deaminated to xanthine. In addition, some guanine is converted to inosinate and adenine nucleotides. Inosinate formed either from hypoxanthine or de novo is readily converted to adenine and guanine nucleotides.
Authors:
P W Burridge; R A Woods; J F Henderson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Canadian journal of biochemistry     Volume:  55     ISSN:  0008-4018     ISO Abbreviation:  Can. J. Biochem.     Publication Date:  1977 Sep 
Date Detail:
Created Date:  1977-11-30     Completed Date:  1977-11-30     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  0421034     Medline TA:  Can J Biochem     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  935-41     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenine / metabolism
Glycine / metabolism
Guanine / metabolism
Hypoxanthines / metabolism
Inosine / metabolism
Purines / metabolism*
RNA / metabolism
Ribonucleosides / metabolism
Ribonucleotides / metabolism
Saccharomyces cerevisiae / metabolism*
Xanthines / metabolism
Chemical
Reg. No./Substance:
0/Hypoxanthines; 0/Purines; 0/Ribonucleosides; 0/Ribonucleotides; 0/Xanthines; 56-40-6/Glycine; 58-63-9/Inosine; 63231-63-0/RNA; 73-24-5/Adenine; 73-40-5/Guanine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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