Document Detail

Purine metabolism and clinical status of patients with rheumatoid arthritis treated with dipyridamole.
MedLine Citation:
PMID:  17065108     Owner:  NLM     Status:  MEDLINE    
The anti-inflammatory activities of methotrexate and sulphasalazine may be mediated by increases in endogenous adenosine levels. Since the vascular protective drug dipyridamole inhibits the uptake and metabolism of adenosine we have now tested this compound in patients with rheumatoid arthritis to assess its effects on their symptoms. Forty patients (aged 18-75 years) received dipyridamole 400 mg/day or placebo. The levels of adenosine and its major metabolites were determined by high performance liquid chromatography (HPLC) in blood samples taken at baseline and at monthly intervals during treatment for 6 months. After three months of treatment there was a significant reduction in the modified Health Assessment Questionnaire (mHAQ) score, but these effects were not maintained, and dipyridamole did not modify disease severity scores or the levels of adenosine and its metabolites. We conclude that the symptoms of rheumatoid arthritis were not modified by treatment with dipyridamole.
C M Forrest; T W Stone; G M Mackay; L Oxford; N Stoy; G Harman; L G Darlington
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nucleosides, nucleotides & nucleic acids     Volume:  25     ISSN:  1525-7770     ISO Abbreviation:  Nucleosides Nucleotides Nucleic Acids     Publication Date:  2006  
Date Detail:
Created Date:  2006-10-26     Completed Date:  2007-01-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892832     Medline TA:  Nucleosides Nucleotides Nucleic Acids     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1287-90     Citation Subset:  IM    
Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK.
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MeSH Terms
Adenosine / blood
Anti-Inflammatory Agents / pharmacology
Arthritis, Rheumatoid / drug therapy*,  metabolism*
Chromatography, High Pressure Liquid / methods
Cytokines / metabolism
Dipyridamole / pharmacology*
Middle Aged
Purines / metabolism*
Vasodilator Agents / pharmacology
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Cytokines; 0/Placebos; 0/Purines; 0/Vasodilator Agents; 58-32-2/Dipyridamole; 58-61-7/Adenosine

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