Document Detail


Purine-containing cucurbitane triterpenoids from Cucurbita pepo cv dayangua.
MedLine Citation:
PMID:  18325551     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Phytochemical investigation of the fruits of Cucurbita pepo cv dayangua led to the isolation of cucurbitaglycosides A (1) and B (2). This is the first report of cucurbitane triterpenoids with a purine unit. Their structures were elucidated mainly based on interpretation of HRESIMS results, as well as 1D and 2D NMR spectra. Cucurbitaglycosides A and B showed cytotoxic activity against the human epithelial carcinoma cell line HeLa with IC50 of 17.2 and 28.4 microg/mL, respectively.
Authors:
Da-Cheng Wang; Hua Xiang; Dan Li; Hui-Yuan Gao; Hui Cai; Li-Jun Wu; Xu-Ming Deng
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-03-05
Journal Detail:
Title:  Phytochemistry     Volume:  69     ISSN:  0031-9422     ISO Abbreviation:  Phytochemistry     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-31     Completed Date:  2008-11-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0151434     Medline TA:  Phytochemistry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1434-8     Citation Subset:  IM    
Affiliation:
School of Veterinary Science, Jilin University, Jilin 130062, China.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents, Phytogenic / chemistry*,  pharmacology*
Cucurbita / chemistry*
Fruit / chemistry
Glycosides / chemistry,  pharmacology
Hela Cells
Humans
Molecular Sequence Data
Molecular Structure
Purines / chemistry*
Triterpenes / chemistry*,  pharmacology*
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Glycosides; 0/Purines; 0/Triterpenes; 0/cucurbitane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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