Document Detail

Purine catabolism in advanced carotid artery plaque.
MedLine Citation:
PMID:  17065109     Owner:  NLM     Status:  MEDLINE    
This study was carried out on carotid artery plaque and plasma of 50 patients. We analyzed uric acid, hypoxanthine, xanthine, and allantoin levels to verify if enzymatic purine degradation occurs in advanced carotid plaque; we also determined free radicals and sulphydryl groups to check if there is a correlation between oxidant status and purine catabolism. Comparing plaque and plasma we found higher levels of free radicals, hypoxanthine, xanthine, and a decrease of some oxidant protectors, such as sulphydryl groups and uric acid, in plaque. We also observed a very important phenomenon in plaque, the presence of allantoin due to chemical oxidation of uric acid, since humans do not have the enzyme uricase. The hypothetical elevated activity of xanthine oxidase in atherosclerosis could be reduced by specific therapies using its inhibitors, such as oxypurinol or allopurinol.
C Felici; I Ciari; L Terzuoli; B Porcelli; C Setacci; M Giubbolini; E Marinello
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nucleosides, nucleotides & nucleic acids     Volume:  25     ISSN:  1525-7770     ISO Abbreviation:  Nucleosides Nucleotides Nucleic Acids     Publication Date:  2006  
Date Detail:
Created Date:  2006-10-26     Completed Date:  2007-01-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892832     Medline TA:  Nucleosides Nucleotides Nucleic Acids     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1291-4     Citation Subset:  IM    
Department of Internal Medicine, Endocrine-Metabolic Sciences and Biochemistry, University of Siena, Siena, Italy.
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MeSH Terms
Aged, 80 and over
Allantoin / blood
Allopurinol / blood
Carotid Stenosis / blood*,  metabolism*
Chemistry, Clinical / methods
Free Radicals
Hypoxanthine / blood
Middle Aged
Oxidants / metabolism
Oxypurinol / blood
Purines / metabolism
Uric Acid / blood,  metabolism
Xanthine / blood
Reg. No./Substance:
0/Free Radicals; 0/Oxidants; 0/Purines; 2465-59-0/Oxypurinol; 315-30-0/Allopurinol; 68-94-0/Hypoxanthine; 69-89-6/Xanthine; 69-93-2/Uric Acid; 97-59-6/Allantoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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