Document Detail


Purified neem (Azadirachta indica) seed extracts (Praneem) abrogate pregnancy in primates.
MedLine Citation:
PMID:  8773426     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The use of neem (Azadirachta indica) seed extracts (Praneem) given orally for abrogation of pregnancy in subhuman primates is described. Oral administration of Praneem was initiated after confirmation of pregnancy using Leydig cell bioassay estimating rising levels of chorionic gonadotropin (CG) in the blood from day 25 onwards of the cycle and continued for six days. Termination of pregnancy was observed with the appearance of blood in the vaginal smears and decline in CG and progesterone. Pregnancy continued in the control animals treated with peanut oil at the same dose. The effect was observed in both baboons and bonnet monkeys. The treatment was well tolerated; blood chemistry and liver function tests had normal values. The animals regained their normal cyclicity in the cycles subsequent to Praneem treatment.
Authors:
S Mukherjee; N K Lohiya; R Pal; M G Sharma; G P Talwar
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Contraception     Volume:  53     ISSN:  0010-7824     ISO Abbreviation:  Contraception     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-11-05     Completed Date:  1996-11-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0234361     Medline TA:  Contraception     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  375-8     Citation Subset:  IM    
Affiliation:
International Center for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India.
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MeSH Terms
Descriptor/Qualifier:
Abortifacient Agents, Nonsteroidal / administration & dosage,  pharmacology*
Administration, Oral
Animals
Chorionic Gonadotropin / blood,  drug effects,  metabolism
Female
Fertility / physiology
Macaca radiata
Male
Menstruation / drug effects
Papio
Plant Extracts / administration & dosage,  pharmacology*
Pregnancy
Pregnancy Outcome
Pregnancy, Animal / drug effects*
Progesterone / blood,  metabolism
Quinine / administration & dosage,  pharmacology*
Time Factors
Uterine Hemorrhage / chemically induced
Vagina / physiology
Chemical
Reg. No./Substance:
0/Abortifacient Agents, Nonsteroidal; 0/Chorionic Gonadotropin; 0/Plant Extracts; 0/Praneem; 130-95-0/Quinine; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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