| Purified Staphylococcus aureus leukotoxin LukM/F' does not trigger inflammation in the bovine mammary gland. | |
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MedLine Citation:
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PMID: 21951578 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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An early recruitment of neutrophils in mammary tissue and milk is considered an important component of the defense of the mammary gland against Staphylococcus aureus. We investigated whether the leukotoxin LukM/F', which is produced by a proportion of mastitis-causing strains of S. aureus, would be able to trigger inflammation in the udder. Infusion of purified LukM/F' toxin in lactating mammary glands did not cause neutrophil influx in milk, showing that the toxin was not able to cause mastitis on its own. Purified LukM/F' did not kill or stimulate mammary epithelial cells in culture. As expected, LukM bound to mammary macrophages and the complete LukM/F' toxin killed these cells, but subcytotoxic LukM/F' concentrations did not induce secretion of IL-8, TNF-α, IL-1β or IL-6 by macrophages. On the contrary, the production of these pro-inflammatory mediators by adhesion-stimulated macrophages was reduced. Overall, these results indicate that purified leukotoxin LukM/F' is not likely to contribute to the initiation of the inflammatory response and could even play an anti-inflammatory role in the mammary gland by inactivating macrophages. |
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Authors:
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Angélina Fromageau; Patricia Cunha; Florence B Gilbert; Pascal Rainard |
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Publication Detail:
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Type: - Date: 2011-9-22 |
Journal Detail:
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Title: Microbial pathogenesis Volume: - ISSN: 1096-1208 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8606191 Medline TA: Microb Pathog Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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INRA, UR 1282 Infectiologie Animale et Santé Publique, IASP Bat. 311, F-37380 Nouzilly, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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