Document Detail

Purification, characterization and mechanism of action of scatter factor from human placenta.
MedLine Citation:
PMID:  1833232     Owner:  NLM     Status:  MEDLINE    
Scatter factor (SF) causes contiguous sheets of epithelium to spread and cells to separate from each other. SF also increases the velocity, area, and reduces the circularity of individual cells. These changes are mediated in part by alterations in protein synthesis, protein phosphorylation, cytoskeletal reorganization, and cell surface components. SF has been purified from the conditioned medium of ras transformed 3T3 cells and human placenta. Sequence information suggests that SF from 3T3 cells is closely related to hepatocyte growth factor. SF is a glycoprotein, but glycosylation is not necessary for its activity. Glycosylation of target cell proteins, however, is required for SF action.
M M Bhargava; Y Li; A Joseph; M Pendergast; R Hofmann; E M Rosen; I D Goldberg
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  EXS     Volume:  59     ISSN:  1023-294X     ISO Abbreviation:  EXS     Publication Date:  1991  
Date Detail:
Created Date:  1991-11-07     Completed Date:  1991-11-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9204529     Medline TA:  EXS     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  63-75     Citation Subset:  IM    
Department of Radiation Oncology, Long Island Jewish Medical Center, Albert Einstein College of Medicine, New Hyde Park, NY 11042.
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MeSH Terms
Cell Line
Cell Movement / drug effects*
Cytokines / isolation & purification*,  pharmacology
Growth Substances / pharmacology
Hepatocyte Growth Factor
Placenta / physiology*
Grant Support
Reg. No./Substance:
0/Cytokines; 0/Growth Substances; 67256-21-7/Hepatocyte Growth Factor

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