Document Detail

Pure white cell aplasia induced by mesalazine in a patient with ulcerative colitis.
MedLine Citation:
PMID:  23321335     Owner:  NLM     Status:  Publisher    
Objectives and importance: Mesalazine is a widely used and generally safe drug for the treatment of chronic inflammatory bowel diseases. Neutropenia rarely complicates this treatment and very few cases have been reported in the literature. CLINICAL PRESENTATION: We report here the case of a patient with ulcerative colitis who developed a severe febrile neutropenia during treatment with mesalazine. INTERVENTION: Drug withdrawal and treatment with granulocyte colony-stimulating factor resulted in a complete and durable remission of cytopenia. Conclusion headings: We recommend periodic blood count monitoring in all patients undergoing treatment with mesalazine.
Francesco Frattini; Silvia Crestani; Pier Paolo Vescovi; Massimo Franchini
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-20
Journal Detail:
Title:  Hematology (Amsterdam, Netherlands)     Volume:  -     ISSN:  1607-8454     ISO Abbreviation:  Hematology     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2013-1-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9708388     Medline TA:  Hematology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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