| Pure primary lateral sclerosis--Case reports. | |
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MedLine Citation:
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PMID: 18262342 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There is still a debate whether primary lateral sclerosis (PLS) is a distinct pathological entity or whether it represents one end of a continuous spectrum of motor neuron disease (MND). In this report we present four PLS patients who have been observed from the time of symptom onset (1990-1999) through January 2007. All of them have had only upper motor neuron (UMN) signs and slow clinical progression. Three patients have been presented with spastic paraparesis. Spasticity was the main clinical feature in demonstrated cases with hyperactive deep tendon reflexes, clonus, and Babinski signs. One patient was presented with spastic dysarthria at the disease onset. Mean disease duration, measured from symptom onset to the present, was 11.5 years in our reported series. All four PLS patients had not developed lower motor neuron (LMN) signs during this time of observation. This prospective analysis of our PLS series is in agreement with data from other studies suggesting that pure PLS cases have a prolonged course of disease with a high level of independence when compared to other MND. |
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Authors:
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Barbara Tomik; Kamila Anna Zur; Andrzej Szczudlik |
Publication Detail:
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Type: Journal Article Date: 2008-02-08 |
Journal Detail:
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Title: Clinical neurology and neurosurgery Volume: 110 ISSN: 0303-8467 ISO Abbreviation: Clin Neurol Neurosurg Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-04-04 Completed Date: 2008-07-15 Revised Date: 2009-10-14 |
Medline Journal Info:
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Nlm Unique ID: 7502039 Medline TA: Clin Neurol Neurosurg Country: Netherlands |
Other Details:
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Languages: eng Pagination: 387-91 Citation Subset: IM |
Affiliation:
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Department of Neurology, Jagiellonian University Medical College, 3 Botaniczna Street, Krakow, Poland. tomik@neuro.cm-uj.krakow.pl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Disease Progression Dysarthria / diagnosis Female Follow-Up Studies Humans Male Motor Neuron Disease / diagnosis* Neurologic Examination Paraparesis, Spastic / diagnosis Prospective Studies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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