Document Detail


Pure eccentric exercise does not activate blood coagulation.
MedLine Citation:
PMID:  15906078     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Eccentric exercise can cause skeletal muscle damage with ultrastructural disruption, inflammation and increased proteolytic enzyme activity. It may be possible that these changes are able to trigger blood coagulation in vivo. The aim of the study was to investigate changes in blood coagulation via the measurement of aPTT, the thrombin potential (total [TTP] and endogenous [ETP], both intrinsic [in] and extrinsic [ex]) and the thrombin generation (prothrombinfragment 1 + 2 [F1 + 2] and thrombin-antithrombin complex [TAT]) after pure eccentric exercise. Seventeen healthy non-smokers (28 +/- 6 years, VO2-peak 59 +/- 7 ml/min/kg) underwent pure eccentric down jumps (9 x 28 isolated down jumps in 90 min, drop from a height of 55 cm), a cycle exercise (90% of the individual anaerobic threshold for 60-90 min) and a control experiment on different days. Blood samples were drawn after a 30-min rest, immediately, and 2 h after exercise. After the cycle exercise, a clear shortening by 12% (P<0.001) in aPTT and an increase in TTPin (13%; P<0.05) and TAT (33%; P<0.05) in comparison to the control experiment were seen, while after eccentric exercise only minimal changes in aPTT and thrombin potential (TTPin, ETPin) and no thrombin generation (F1 + 2 and TAT) were found. In contrast to concentric dynamic exercise, e.g. cycle ergometry, only insignificant changes in thrombin potential and no thrombin generation could be observed after skeletal muscle damage induced by pure eccentric exercise. It can be concluded that the mechanical impact associated with eccentric exercise does not activate blood coagulation.
Authors:
Thomas Hilberg; Doreen Gläser; Dagmar Prasa; Jörg Stürzebecher; Holger H W Gabriel
Related Documents :
3362978 - Reliability of measurements of concentric and eccentric isokinetic loading.
15705028 - Rest-interval length affects leukocyte levels during heavy resistance exercise.
17661068 - The influence of eccentric exercise on mrna expression of skeletal muscle regulators.
14652498 - A dietary supplement attenuates il-6 and crp after eccentric exercise in untrained males.
10634948 - In vivo behavior of epoxy-crosslinked porcine heart valve cusps and walls.
2365028 - Aerobic metabolism and swimming energetics of the painted turtle, chrysemys picta.
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial     Date:  2005-05-20
Journal Detail:
Title:  European journal of applied physiology     Volume:  94     ISSN:  1439-6319     ISO Abbreviation:  Eur. J. Appl. Physiol.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-07-26     Completed Date:  2005-10-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  718-21     Citation Subset:  IM    
Affiliation:
Department of Sports Medicine, Friedrich-Schiller-University Jena, Wöllnitzerstr. 42, 07749 Jena, Germany. thomas.hilberg@uni-jena.de
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Blood Coagulation / physiology*
Blood Coagulation Tests
Cumulative Trauma Disorders / blood,  etiology,  physiopathology
Exercise Movement Techniques / adverse effects*
Humans
Male
Muscle, Skeletal / injuries,  physiology*
Physical Endurance / physiology*
Physical Exertion / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cardiac vagal tone, exercise performance and the effect of respiratory training.
Next Document:  Whole-body heating slows carotid baroreflex response in human subjects.