| Pure XY gonadal dysgenesis and agenesis in monozygotic twins. | |
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MedLine Citation:
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PMID: 16580399 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To report a case of monozygotic twin sisters who had discordant gonadal dysgenesis although each had a normal 46,XY karyotype. DESIGN: Case report. SETTING: University tertiary hospital. PATIENT(S): Seventeen-year-old twin sisters, one with gonadal agenesis and the other with pure gonadal dysgenesis followed by dysgerminoma. INTERVENTION(S): Blood samples were obtained for karyotyping and short tandem repeat polymorphism analysis (10 markers). Both patients underwent gonadectomy. MAIN OUTCOME MEASURE(S): Both sisters are well at time of report after gonadectomy for the sister with dysgerminoma and diagnostic laparoscope for the other. RESULT(S): Dysgerminoma and atrophic ovarian stromal and tubal structures. CONCLUSION(S): Monozygotic twins can have discordant gonadal dysgenesis even though they are identical genetically. |
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Authors:
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Hui-Yu Chen; Hong-Yuan Huang; Ting-Chang Chang; Chyong-Huey Lai; Yung-Kuei Soong |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Fertility and sterility Volume: 85 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-04-03 Completed Date: 2006-05-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 1059.e9-11 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Lin-Kou Medical Center, Kwei-Shan, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Dysgerminoma / genetics*, pathology Female Gonadal Dysgenesis, 46,XY / genetics*, pathology Humans Ovarian Neoplasms / genetics*, pathology Twins, Monozygotic / genetics* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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