Document Detail

Pure FSH (Metrodin) for ovarian stimulation in the IVF-ET programme.
MedLine Citation:
PMID:  7736649     Owner:  NLM     Status:  MEDLINE    
PURPOSE: a comparative analysis of the clinical effectiveness of pure FSH (Metrodin) and conventional gonadotropin (Pergonal) for ovarian stimulation was performed. METHODS: each group consisted of 30 selected patients with tubal infertility, practically identical by average age, duration of infertility, age at menarche, weight and height and husband's semen analysis. The average number of vials of drug used for stimulation, number of oocytes retrieved and embryos transferred was the same for both groups of patients. The failure of oocyte retrieval and fertilization was higher in the Pergonal (16.8%) than in the Metrodin group (6.8%). RESULTS: in both groups there were 8 pregnancies--4 in the Pergonal and 4 in Metrodin group. All pregnancies in the pure FSH group resulted in the delivery of a healthy baby, while in the Pergonal group there were two deliveries and two spontaneous abortions. AUTHOR'S CONCLUSIONS: evaluating the data we can conclude that pure FSH stimulation provides respectively lower failure and spontaneous abortion rates than Pergonal stimulation, leading to a higher take home baby rate.
H Meden-Vrtovec
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Clinical and experimental obstetrics & gynecology     Volume:  22     ISSN:  0390-6663     ISO Abbreviation:  Clin Exp Obstet Gynecol     Publication Date:  1995  
Date Detail:
Created Date:  1995-06-02     Completed Date:  1995-06-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7802110     Medline TA:  Clin Exp Obstet Gynecol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  9-13     Citation Subset:  IM    
University Department of Obstetrics and Gynecology, Ljubljana, Slovenia.
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MeSH Terms
Embryo Transfer
Fertilization in Vitro
Follicle Stimulating Hormone / pharmacology*
Menotropins / pharmacology
Ovary / drug effects*
Reproductive Techniques*
Treatment Outcome
Reg. No./Substance:
61489-71-2/Menotropins; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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