Document Detail


The pur protein family: genetic and structural features in development and disease.
MedLine Citation:
PMID:  23018800     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Pur proteins are an ancient family of sequence-specific single-stranded nucleic acid-binding proteins. They bind a G-rich element in either single- or double-stranded nucleic acids and are capable of displacing the complementary C-rich strand. Recently several reports have described Pur family member knockouts, mutations, and disease aberrations. Together with a recent crystal structure of Purα, these data reveal conserved structural features of these proteins that have been adapted to serve functions unique to higher eukaryotes. In humans Pur proteins are critical for myeloid cell development, muscle development, and brain development, including trafficking of mRNA to neuronal dendrites. Pur family members have been implicated in diseases as diverse as cancer, premature aging, and fragile-X mental retardation syndrome.
Authors:
Edward M Johnson; Dianne C Daniel; Jennifer Gordon
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of cellular physiology     Volume:  228     ISSN:  1097-4652     ISO Abbreviation:  J. Cell. Physiol.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-01-28     Completed Date:  2013-04-03     Revised Date:  2013-08-23    
Medline Journal Info:
Nlm Unique ID:  0050222     Medline TA:  J Cell Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  930-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Wiley Periodicals, Inc.
Affiliation:
Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507-1696, USA. johnsoEM@evms.edu
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
DNA-Binding Proteins* / chemistry,  genetics
Fragile X Syndrome* / genetics,  metabolism
Gene Knockout Techniques
Humans
Mice
Molecular Sequence Data
Muscle Development*
Neoplasms* / genetics,  metabolism
Transcription Factors* / chemistry,  genetics
Grant Support
ID/Acronym/Agency:
P01 NS036466/NS/NINDS NIH HHS; P01 NS043980/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Transcription Factors; 0/c-MYC-associated zinc finger protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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