Document Detail

Pupillary light reflex in panic disorder. A trial using audiovisual stimulation.
MedLine Citation:
PMID:  15309394     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although many previous studies reported abnormalities of autonomic function in patients with panic disorder (PD), almost all targets in those studies primarily focused on cardiovascular autonomic functions. In the present study, we determined whether PD patients exhibited abnormalities in the pupillary autonomic nervous system (ANS). METHODS: Before and after audiovisual stimulation (AS), which induced mental stress through exposure to video images of high stress experiences, such as driving motor vehicles, the pupillary light reflex (PLR) was measured by infrared pupillometer in 13 remitted PD patients and twenty age- and gender-matched normal controls (NC). RESULTS: Before and after AS, there were no significant differences in initial pupillary diameters in dark conditions (D1), pupillary diameters at maximum constriction (D2) or constriction ratios (CR: (D1-D2)/D1) between PD and NC subjects. However, the CR ratio (CR before/CR after) was significantly higher in the PD group than in the NC. CONCLUSIONS: These findings suggest that even remitted PD patients may have a dysfunctional PLR regulation with experimental stressors such as AS.
Maki Kojima; Toshiki Shioiri; Toshihiro Hosoki; Hideaki Kitamura; Takehiko Bando; Toshiyuki Someya
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European archives of psychiatry and clinical neuroscience     Volume:  254     ISSN:  0940-1334     ISO Abbreviation:  Eur Arch Psychiatry Clin Neurosci     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-08-13     Completed Date:  2004-10-04     Revised Date:  2009-05-11    
Medline Journal Info:
Nlm Unique ID:  9103030     Medline TA:  Eur Arch Psychiatry Clin Neurosci     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  242-4     Citation Subset:  IM    
Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi, Niigata 951-8510, Japan.
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MeSH Terms
Panic Disorder / physiopathology*
Physical Stimulation / methods
Reflex, Pupillary / physiology*

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