Document Detail

Pupillary constriction during haloperidol treatment as a predictor of relapse following drug withdrawal in schizophrenic patients.
MedLine Citation:
PMID:  1438625     Owner:  NLM     Status:  MEDLINE    
It has been proposed that the autonomic nervous system is dysregulated in schizophrenia. We hypothesized that measures of autonomic function, even during neuroleptic stabilization, might predict relapse following withdrawal of medication. Previously, shorter latencies to maximum pupillary constriction have been reported to differentiate acutely hospitalized schizophrenic patients from control subjects. Pupillary light reactions were recorded weekly from 19 chronic schizophrenic inpatients who were initially maintained on haloperidol and subsequently were withdrawn from medication under double-blind, placebo-controlled conditions. Patients were then classified as either relapsed or nonrelapsed (clinically stable) during the drug-free period. During the treatment phase, a shorter latency to maximum pupillary constriction significantly distinguished patients who were later to relapse from the nonrelapsers. The potential use of autonomic activity as an indicator of prodromal sensitivity was supported. In addition, these findings emphasize the need for classification of drug-free patients according to clinical status.
S R Steinhauer; D P van Kammen; K Colbert; J L Peters; J Zubin
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Psychiatry research     Volume:  43     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1992-12-18     Completed Date:  1992-12-18     Revised Date:  2008-04-17    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  287-98     Citation Subset:  IM    
Biometrics Research Program, VA Medical Center, Pittsburgh, PA 15206.
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MeSH Terms
Arousal / drug effects*,  physiology
Double-Blind Method
Haloperidol / adverse effects*,  therapeutic use
Middle Aged
Neurologic Examination / drug effects
Psychiatric Status Rating Scales
Reaction Time / drug effects,  physiology
Reflex, Pupillary / drug effects*,  physiology
Schizophrenia / diagnosis,  drug therapy*,  physiopathology
Schizophrenic Psychology*
Substance Withdrawal Syndrome / diagnosis*,  physiopathology,  psychology
Grant Support
Reg. No./Substance:

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