Document Detail

Pupillary abnormality on admission and brain bulging during surgery as unfavourable predictors in patients treated with hypothermia: a retrospective review of 81 patients with severe head injury.
MedLine Citation:
PMID:  11810387     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: To determine factors predicting outcome of patients with severe head injury, the authors retrospectively analyzed 81 patients, 3 to 70 years of age, who were treated by hypothermia. METHOD: The initial Glasgow Coma Scale scores of the 81 patients ranged from 3 to 8. Outcome in each case was determined at six months after injury and was retrospectively analyzed with respect to patient characteristics, initial clinical status, laboratory data, computed tomographic findings, data from monitoring, intra-operative findings, and treatment methods. The significance of clinical and neuroradiological factors for predicting unfavorable outcome was analyzed by univariate logistic regression. Stepwise multiple logistic regression analysis was then used to identify independent predictors of outcome. FINDINGS: Favorable outcome was observed in 27 of 81 patients treated by hypothermia. Independent factors predicting unfavorable outcome included pupillary abnormality on admission and brain bulging during surgery. INTERPRETATION: Therapeutic effectiveness of hypothermia was thus limited in patients who presented with these grave symptoms.
M Matsumae; H Ishizaka; H Shiramizu; M Shibata; R Tsugane
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta neurochirurgica     Volume:  143     ISSN:  0001-6268     ISO Abbreviation:  Acta Neurochir (Wien)     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2002-01-25     Completed Date:  2002-02-20     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0151000     Medline TA:  Acta Neurochir (Wien)     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  1229-34; discussion 1234-5     Citation Subset:  IM    
Department of Neurosurgery, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
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MeSH Terms
Brain Edema*
Child, Preschool
Craniocerebral Trauma / classification,  pathology*,  therapy
Hypothermia, Induced*
Middle Aged
Predictive Value of Tests
Pupil Disorders / etiology*,  pathology
Retrospective Studies
Risk Factors
Severity of Illness Index
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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