| Pupil diameter in darkness differentiates progressive supranuclear palsy (PSP) from other extrapyramidal syndromes. | |
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MedLine Citation:
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PMID: 17853484 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The most important features that characterize and differentiate progressive supranuclear palsy from other Parkinsonian syndromes are postural instability, supranuclear gaze palsy, pseudobulbar palsy, parkinsonism, and cognitive disturbances. In this article, we demonstrate that progressive supranuclear palsy patients exhibit pathologically decreased pupil diameters after dark adaptation recorded by TV pupillography. A cut off value of 3.99 mm was defined to differentiate progressive supranuclear palsy patients from patients with other extrapyramidal disorders like Parkinson's disease and multiple system atrophy with a specificity of 86.4% and a sensitivity of 70.8%. Other pupil abnormalities could not be described in patients with extrapyramidal syndromes. |
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Authors:
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Claudia Schmidt; Birgit Herting; Silke Prieur; Susann Junghanns; Katherine Schweitzer; Christoph Globas; Ludger Schöls; Sabine Antoni; Dietmar Ferger; Heinz Reichmann; Helmut Wilhelm; Daniela Berg; Tjalf Ziemssen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Movement disorders : official journal of the Movement Disorder Society Volume: 22 ISSN: 0885-3185 ISO Abbreviation: Mov. Disord. Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-11-05 Completed Date: 2008-02-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8610688 Medline TA: Mov Disord Country: United States |
Other Details:
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Languages: eng Pagination: 2123-6 Citation Subset: IM |
Copyright Information:
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(c) 2007 Movement Disorder Society. |
Affiliation:
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Autonomic and Neuroendocrinological Laboratory, University Clinic Carl Gustav Carus, Dresden University of Technology, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Case-Control Studies Darkness* Female Humans Male Middle Aged Multiple System Atrophy / complications Parkinson Disease / complications Pupil / physiology* Supranuclear Palsy, Progressive / etiology, pathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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