Document Detail


Pup circadian rhythm entrainment--effect of maternal ganglionectomy or pinealectomy.
MedLine Citation:
PMID:  16899263     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In rodents, during late embryonic and early neonatal development, circadian rhythms develop in synchrony with those of their mothers, which in turn are synchronized with the environmental photoperiod. This paper examines the effect of maternal ganglionectomy (pineal gland sympathetic denervation) or extirpation of the pineal gland on pups' drinking rhythms, a behavior that is continuously monitored in individual animals starting after weaning and studied up to 3 weeks later. Maternal ganglionectomy or pinealectomy performed on the 7th day of gestation significantly disrupts rat pups' drinking behavior, within and among litters. In both treatments, circadian rhythm characteristics of the free-running period (tau), phase, amplitude and alpha were significantly altered compared to those of the control pups born from sham-operated mothers. With the exception of the alpha component, both maternal treatments have similar effects. When melatonin was given to the mothers instead of the endogenous pineal secretory activity for 5 days during the late period of gestation, this treatment reversed the effects of maternal ganglionectomy and pinealectomy. These observations, together with previous studies of our group, indicate that the maternal superior cervical ganglia and pineal gland are necessary components of the mechanism for maternal synchronization, and that maternal melatonin may, directly or indirectly, affect the performance of the pups' central oscillator during early pup rat development.
Authors:
S L Bellavía; A R Carpentieri; A M Vaqué; A F Macchione; N T Vermouth
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-08-08
Journal Detail:
Title:  Physiology & behavior     Volume:  89     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-02     Completed Date:  2006-12-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  342-9     Citation Subset:  IM    
Affiliation:
Cátedra de Bioquímica y Biología Molecular, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, CC 35, 5016 Córdoba, Argentina. sbellavia@biomed.uncor.edu
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Animals, Newborn
Behavior, Animal / drug effects,  physiology
Circadian Rhythm / drug effects,  physiology*
Drinking Behavior / physiology
Female
Ganglionectomy*
Male
Melatonin / pharmacology
Motor Activity / drug effects,  physiology
Pineal Gland / physiology*,  surgery
Pregnancy
Prenatal Exposure Delayed Effects*
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
73-31-4/Melatonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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