Document Detail

Punctate pemphigus: an underreported direct immunofluorescence pattern.
MedLine Citation:
PMID:  24372009     Owner:  NLM     Status:  MEDLINE    
Intercellular epidermal deposition of immunoglobulin G (IgG) in a continuous net-like or 'chicken wire' pattern is a well-described and diagnostic finding in direct immunofluorescence (DIF) studies of pemphigus. In our experience, punctate or dot-like intercellular deposition of IgG can also be seen in cases of pemphigus but has received little attention in the literature. We describe a series of DIF specimens showing intercellular deposition of IgG in continuous and/or punctate patterns, which occurred with equal frequency in pemphigus vulgaris and pemphigus foliaceus. This series highlights the punctate or dot-like pattern of intercellular IgG deposition in DIF studies of pemphigus, reviews potential mechanisms and calls attention to this potentially under-recognized phenomenon.
Christine J Ko; Jennifer M McNiff
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Publication Detail:
Type:  Journal Article     Date:  2013-12-24
Journal Detail:
Title:  Journal of cutaneous pathology     Volume:  41     ISSN:  1600-0560     ISO Abbreviation:  J. Cutan. Pathol.     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-03-04     Completed Date:  2014-10-20     Revised Date:  2014-10-30    
Medline Journal Info:
Nlm Unique ID:  0425124     Medline TA:  J Cutan Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  293-6     Citation Subset:  IM    
Copyright Information:
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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MeSH Terms
Immunoglobulin G / metabolism*
Immunohistochemistry / methods
Pemphigus / metabolism*,  pathology*
Retrospective Studies
Reg. No./Substance:
0/Immunoglobulin G
Comment In:
J Cutan Pathol. 2014 Sep;41(9):756-7   [PMID:  24975993 ]
J Cutan Pathol. 2014 Sep;41(9):758   [PMID:  24995606 ]

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