| Punctal occlusion in the management of chronic Stevens-Johnson syndrome. | |
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MedLine Citation:
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PMID: 15121365 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate the effect of lacrimal punctal occlusion in the management of the ocular surface disease in chronic Stevens-Johnson syndrome. DESIGN: Retrospective noncomparative case series. PARTICIPANTS: Thirty-one eyes of 18 patients with chronic Stevens-Johnson syndrome seen at the Department of Ophthalmology of the Tokyo Dental College were studied. INTERVENTION: Patients' lacrimal puncta were occluded by cauterization or with punctal plugs. MAIN OUTCOME MEASURES: The effect of lacrimal punctal occlusion was evaluated by changes in subjective symptoms, best-corrected visual acuity (VA), Schirmer test, tear clearance test, and ocular surface double vital staining before and after punctal occlusion. RESULTS: After lacrimal punctal occlusion, symptomatic improvement was observed in 19 eyes (61.3%). The mean logarithmic VA showed significant improvement from -0.64+/-0.87 to -0.52+/-0.86 (P<0.05). The Schirmer I test results before punctal occlusion yielded a mean score of 7.4+/-8.7 mm, which changed to 10.2+/-8.3 mm after punctal occlusion. The mean preocclusion and postocclusion tear clearance values were 7.5+/-6.6 times and 4.9+/-4.8 times, respectively. The Rose Bengal staining score decreased from 4.7+/-2.8 to 2.7+/-2.2 points (P<0.05), and the fluorescein staining score decreased from 5.0+/-2.3 to 2.2+/-2.5 points (P<0.05), respectively. CONCLUSIONS: Concurrent improvements in subjective symptoms, vital staining scores, and VA point to the favorable effects of lacrimal punctal occlusion for the ocular surface health in chronic Stevens-Johnson syndrome. |
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Authors:
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Minako Kaido; Eiki Goto; Murat Dogru; Kazuo Tsubota |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Ophthalmology Volume: 111 ISSN: 0161-6420 ISO Abbreviation: Ophthalmology Publication Date: 2004 May |
Date Detail:
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Created Date: 2004-05-03 Completed Date: 2004-05-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7802443 Medline TA: Ophthalmology Country: United States |
Other Details:
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Languages: eng Pagination: 895-900 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Tokyo Dental College, Ichikawa, Japan. fwiw1193@mb.infoweb.ne.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Cautery Child Chronic Disease Dry Eye Syndromes / etiology, metabolism, surgery* Female Fluorescein Fluorophotometry Humans Lacrimal Apparatus / surgery* Male Middle Aged Prostheses and Implants Retrospective Studies Rose Bengal Stevens-Johnson Syndrome / complications, metabolism, surgery* Tears / secretion Visual Acuity |
| Chemical | |
Reg. No./Substance:
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11121-48-5/Rose Bengal; 2321-07-5/Fluorescein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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