| Punc, a novel mouse gene of the immunoglobulin superfamily, is expressed predominantly in the developing nervous system. | |
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MedLine Citation:
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PMID: 9507132 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A search for genes regulated by the LlM/homeodomain transcription factor islet-1 during development identified the novel mouse gene punc (putative neuronal cell adhesion molecule). Punc is a member of the immunoglobulin superfamily, exhibits a novel configuration of four immunoglobulin domains and two fibronectin-type III repeats, and resembles proteins involved in axon guidance. Punc expression in the embryo occurs in restricted patterns in both the nervous system and limb mesoderm. A sharp decrease in punc expression after embryonic day 11.5 suggests a function for punc early in mouse embryogenesis. |
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Authors:
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J M Salbaum |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Mechanisms of development Volume: 71 ISSN: 0925-4773 ISO Abbreviation: Mech. Dev. Publication Date: 1998 Feb |
Date Detail:
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Created Date: 1998-06-16 Completed Date: 1998-06-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9101218 Medline TA: Mech Dev Country: IRELAND |
Other Details:
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Languages: eng Pagination: 201-4 Citation Subset: IM |
Affiliation:
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The Neurosciences Institute, San Diego, CA 92121, USA.salbaum@nsi.edu |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/AF026465 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Cell Adhesion Molecules, Neuronal / biosynthesis, genetics* Immunoglobulins / biosynthesis, genetics* Mice Molecular Sequence Data Multigene Family* Nervous System / embryology*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Cell Adhesion Molecules, Neuronal; 0/Immunoglobulins; 0/Punc protein, mouse |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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