Document Detail


A pumpless lung assist device reduces mechanical ventilation-induced lung injury in juvenile piglets.
MedLine Citation:
PMID:  19687779     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Respiratory failure is a major contributor to mortality and morbidity in newborn infants. The lung assist device (LAD) is a novel gas exchange device that supplements mechanical ventilation. The objective is to test the effect of the LAD on pulmonary histopathology in juvenile piglets with acute lung injury caused by saline lung lavage (SLL) followed by intermittent mandatory ventilation (IMV). Three- to 4-wk-old piglets were randomized to no intervention (control group), SLL alone (SLL group), SLL + IMV (IMV group), or SLL + IMV + LAD (LAD group) (n = 6 per group). The carotid artery and jugular vein were cannulated and an arteriovenous circuit completed, and the LAD was inserted into this circuit. Gas exchange via the LAD was initiated by passage of 100% oxygen over the blood-carrying hollow fibers of the LAD. Hemodynamic variables were recorded. Mechanical ventilation was systematically weaned. Lung histology was scored by two observers masked to treatment group. There were no differences in hemodynamic variables between the study groups. There was a significant increase in the total lung injury score in the IMV group compared with the LAD group. The novel pumpless low-resistance LAD has shown feasibility and potential to decrease ventilator-induced lung injury in a juvenile animal model.
Authors:
George T El-Ferzli; Joseph B Philips; Arlene Bulger; Namasivayam Ambalavanan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  66     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-18     Completed Date:  2010-03-22     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  671-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Blood Pressure
Heart Rate
Oximetry
Oxygenators*
Pulmonary Gas Exchange / physiology*
Respiration, Artificial / instrumentation*,  methods
Sus scrofa
Ventilator-Induced Lung Injury / pathology,  prevention & control*
Grant Support
ID/Acronym/Agency:
K08 HD046513/HD/NICHD NIH HHS; K08 HD046513/HD/NICHD NIH HHS; K08 HD046513-02/HD/NICHD NIH HHS; R01 HL092906/HL/NHLBI NIH HHS
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