Document Detail


Pumiliotoxin B-like alkaloid in extracts of the skin of the Australian myobatrachid frog Pseudophryne coriacea: effects on the systemic blood pressure of experimental animals and the rat heart.
MedLine Citation:
PMID:  2747845     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Semi-purified extracts of the skin of the Australian myobatrachid frog Pseudophryne coriacea (PS)displayed striking, reversible and, in part, dose-dependent effects on the systemic blood pressure of the rat and other experimental animals, as well as on the rat heart. The blood pressure response in the rat consisted typically in an abrupt, short-lasting fall, followed by a conspicuous, more persistent rise. The fall in pressure was abolished by atropine and potentiated by physostigmine, indicating a cholinergic mechanism; rise was abolished by prazosin and guanethidine, suggesting a release of catecholamines from adrenergic nerve terminals in the vasculature. Tachyphylaxis was the obvious result of exhaustion of stores of catecholamines. On the heart, as shown in the electrocardiographic tracings, PS produced a variety of rhythm disorders, attributable both to the release of aminergic transmitters and to a direct effect on the myocardium. Whereas the pressure and electrocardiographic responses were virtually unaffected by calcium channel antagonists and agonists, all the effects of PS were sharply reduced or completely abolished by the sodium channel blocker tetrodotoxin. This suggests that activation of sodium channels may play a role in the mechanism of action of PS. However, the exact nature of ionic flux(es)influenced by the extract of frog skin remains to be established.
Authors:
G F Erspamer; C Severini; V Erspamer; P Melchiorri
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuropharmacology     Volume:  28     ISSN:  0028-3908     ISO Abbreviation:  Neuropharmacology     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-08-17     Completed Date:  1989-08-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0236217     Medline TA:  Neuropharmacology     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  319-28     Citation Subset:  IM    
Affiliation:
Institute of Medical Pharmacology III, University of Rome La Sapienza, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adrenalectomy
Alkaloids / analysis*
Animals
Anura
Arrhythmias, Cardiac / physiopathology
Autonomic Agents / pharmacology
Blood Pressure / drug effects*
Calcium / physiology
Dogs
Electrocardiography
Guinea Pigs
Heart / drug effects*
Indolizines*
Male
Oxygen Consumption / drug effects
Piperidines*
Rabbits
Rats
Rats, Inbred Strains
Salivation / drug effects
Skin Physiological Phenomena*
Sodium / physiology
Tissue Extracts / pharmacology*
Chemical
Reg. No./Substance:
0/Alkaloids; 0/Autonomic Agents; 0/Indolizines; 0/Piperidines; 0/Tissue Extracts; 67016-65-3/pumiliotoxin B; 7440-23-5/Sodium; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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