Document Detail

Pumiliotoxin B-like alkaloid in extracts of the skin of the Australian myobatrachid frog Pseudophryne coriacea: effects on the systemic blood pressure of experimental animals and the rat heart.
MedLine Citation:
PMID:  2747845     Owner:  NLM     Status:  MEDLINE    
Semi-purified extracts of the skin of the Australian myobatrachid frog Pseudophryne coriacea (PS)displayed striking, reversible and, in part, dose-dependent effects on the systemic blood pressure of the rat and other experimental animals, as well as on the rat heart. The blood pressure response in the rat consisted typically in an abrupt, short-lasting fall, followed by a conspicuous, more persistent rise. The fall in pressure was abolished by atropine and potentiated by physostigmine, indicating a cholinergic mechanism; rise was abolished by prazosin and guanethidine, suggesting a release of catecholamines from adrenergic nerve terminals in the vasculature. Tachyphylaxis was the obvious result of exhaustion of stores of catecholamines. On the heart, as shown in the electrocardiographic tracings, PS produced a variety of rhythm disorders, attributable both to the release of aminergic transmitters and to a direct effect on the myocardium. Whereas the pressure and electrocardiographic responses were virtually unaffected by calcium channel antagonists and agonists, all the effects of PS were sharply reduced or completely abolished by the sodium channel blocker tetrodotoxin. This suggests that activation of sodium channels may play a role in the mechanism of action of PS. However, the exact nature of ionic flux(es)influenced by the extract of frog skin remains to be established.
G F Erspamer; C Severini; V Erspamer; P Melchiorri
Related Documents :
25207105 - Recruitment maneuver does not increase the risk of ventilator induced lung injury.
2627695 - Hypotensive properties of antibodies directed against an endogenous pressor peptide iso...
3665195 - The effect of endogenous opioids on blood pressure during stress.
4014485 - Hemodynamic effects of arginine vasopressin in conscious water-deprived rats.
9783295 - The effects of nitrous oxide on pediatric dental patients sedated with chloral hydrate ...
1490935 - Heart energetic efficiency in o2-exposed rats studied in isolated working heart.
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuropharmacology     Volume:  28     ISSN:  0028-3908     ISO Abbreviation:  Neuropharmacology     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-08-17     Completed Date:  1989-08-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0236217     Medline TA:  Neuropharmacology     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  319-28     Citation Subset:  IM    
Institute of Medical Pharmacology III, University of Rome La Sapienza, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Alkaloids / analysis*
Arrhythmias, Cardiac / physiopathology
Autonomic Agents / pharmacology
Blood Pressure / drug effects*
Calcium / physiology
Guinea Pigs
Heart / drug effects*
Oxygen Consumption / drug effects
Rats, Inbred Strains
Salivation / drug effects
Skin Physiological Phenomena*
Sodium / physiology
Tissue Extracts / pharmacology*
Reg. No./Substance:
0/Alkaloids; 0/Autonomic Agents; 0/Indolizines; 0/Piperidines; 0/Tissue Extracts; 67016-65-3/pumiliotoxin B; 7440-23-5/Sodium; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Fibre disorganization in the neocortex of patients with senile dementia of the Alzheimer type.
Next Document:  The effects of gepirone and 1-(2-pyrimidinyl)-piperazine on levels of corticosterone in rat plasma.